Functional connectivity-based subtypes of individuals with and without autism spectrum disorder
Functional connectivity-based subtypes of individuals with and without autism spectrum disorder
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DOI：
10.1162/netn_a_00067
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发表时间：
2019-01-01
影响因子：
4.7
通讯作者：
McIntosh, Anthony R.
中科院分区：
文献类型：
--
作者：
Easson, Amanda K.;Fatima, Zainab;McIntosh, Anthony R.
自闭症谱系障碍（ASD）是一种异质性神经发育障碍，其特征是社会沟通障碍和限制性重复行为。神经影像学研究显示ASD中存在复杂的模式和功能连接（FC），但在大脑-行为关系或FC与典型发育对照的共享模式方面没有明确的共识。在这里，我们使用了一个维度的方法来表征两个不同的集群的FC模式在ASD参与者和控制使用k均值聚类。使用多变量统计分析，采用分类方法来表征亚型之间和诊断组之间的FC差异。一种亚型定义为静息状态网络内FC增加，而另一种亚型则定义为网络间FC减少。一个单独的FC模式区分ASD从控制，特别是在默认模式，扣带-盖，感觉运动，枕叶网络。亚型和诊断组之间没有显著的相互作用。最后，一个维度分析的FC模式与行为措施的智商，社会反应，和ASD的严重程度显示独特的脑行为关系，在每个亚型和连续的脑行为关系，从ASD控制在一个亚型。这些结果表明，在ASD和对照组中存在不同的FC模式簇，并且FC亚型可以揭示关于脑行为关系的独特信息。自闭症谱系障碍（ASD）是一种神经发育障碍，在社会交往和限制，重复行为的损害严重程度的类型有很大的变化。神经影像学研究表明，ASD患者大脑区域之间的通信模式或功能连接（FC）复杂。在这里，我们定义了两个不同的FC模式和FC和行为之间的关系，在一组参与者组成的个人和没有ASD。与另一种亚型相比，一种亚型的定义是不同大脑区域网络内的FC增加，而网络之间的FC减少。一个单独的FC模式区分ASD从控制。亚型与诊断组之间的相互作用不显著。FC模式与行为措施的维度分析揭示了独特的信息，在每个亚型的脑行为关系。
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder, characterized by impairments in social communication and restricted, repetitive behaviors. Neuroimaging studies have shown complex patterns and functional connectivity (FC) in ASD, with no clear consensus on brain-behavior relationships or shared patterns of FC with typically developing controls. Here, we used a dimensional approach to characterize two distinct clusters of FC patterns across both ASD participants and controls using k-means clustering. Using multivariate statistical analyses, a categorical approach was taken to characterize differences in FC between subtypes and between diagnostic groups. One subtype was defined by increased FC within resting-state networks and decreased FC across networks compared with the other subtype. A separate FC pattern distinguished ASD from controls, particularly within default mode, cingulo-opercular, sensorimotor, and occipital networks. There was no significant interaction between subtypes and diagnostic groups. Finally, a dimensional analysis of FC patterns with behavioral measures of IQ, social responsiveness, and ASD severity showed unique brain-behavior relations in each subtype and a continuum of brain-behavior relations from ASD to controls within one subtype. These results demonstrate that distinct clusters of FC patterns exist across ASD and controls, and that FC subtypes can reveal unique information about brain-behavior relationships. Author SummaryAutism spectrum disorder (ASD) is a neurodevelopmental disorder, with high variation in the types of severity of impairments in social communication and restricted, repetitive behaviors. Neuroimaging studies have shown complex patterns of communication between brain regions, or functional connectivity (FC), in ASD. Here, we defined two distinct FC patterns and relationships between FC and behavior in a group of participants consisting of individuals with and without ASD. One subtype was defined by increased FC within distinct networks of brain regions and decreased FC between networks compared with the other subtype. A separate FC pattern distinguished ASD from controls. The interaction between subtypes and diagnostic groups was not significant. Dimensional analyses of FC patterns with behavioral measures revealed unique information about brain-behavior relations in each subtype.