Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity.
Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity.
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DOI：
10.1016/j.tibtech.2016.09.002
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发表时间：
2017-03
影响因子：
17.3
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Tan P;He L;Han G;Zhou Y
基于微生物视蛋白的光遗传学工具已经为神经科学带来了变革。为了将光遗传学方法扩展到免疫系统以用上级时空精度远程控制免疫应答，最近已经制作了开拓性工具以通过工程化趋化因子受体和钙释放激活的钙通道的光活化来调节淋巴细胞运输、炎性小体激活、树突状细胞成熟和抗肿瘤免疫。我们在此强调了一些概念设计策略，用于将光敏感性安装到免疫信号网络中，同时，我们提出了具有近红外光响应上转换纳米材料的活生物体内光遗传学应用的潜在解决方案。此外，为了超越概念验证进入转化应用，我们讨论了将个性化免疫工程与光遗传学相结合以克服癌症免疫治疗中的关键障碍的未来前景。
Microbial opsin-based optogenetic tools have been transformative for neuroscience. To extend optogenetic approaches to the immune system to remotely control immune responses with superior spatiotemporal precision, pioneering tools have recently been crafted to modulate lymphocyte trafficking, inflammasome activation, dendritic cell maturation, and antitumor immunity through the photoactivation of engineered chemokine receptors and calcium release-activated calcium channels. We highlight herein some conceptual design strategies for installing light sensitivities into the immune signaling network, and in parallel, we propose potential solutions for in vivo optogenetic applications in living organisms with near-infrared light-responsive upconversion nanomaterials. Moreover, to move beyond proof-of-concept into translational applications, we discuss future prospects for integrating personalized immunoengineering with optogenetics to overcome critical hurdles in cancer immunotherapy.