herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells
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DOI：
10.1158/0008-5472.can-03-2360
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发表时间：
2004-01-15
期刊：
影响因子：
11.2
通讯作者：
Arcangeli, A
中科院分区：
文献类型：
--
作者：
Lastraioli, E;Guasti, L;Arcangeli, A
获得侵入周围组织的能力赋予肿瘤细胞更恶性的表型，并且对于转移的建立是必需的。了解人类实体瘤（如结直肠癌）细胞侵袭的分子机制不仅可以提供更灵敏的预后分析，而且可以为癌症治疗提供新的分子靶点，我们在这篇文章中报道，属于HERG家族的K+离子通道是结直肠癌侵袭性表型获得的重要决定因素。Herg1基因和HERG 1蛋白在许多结肠癌细胞系中表达，HERG通道的活性调节结肠癌细胞的侵袭力。此外，HERG 1蛋白在细胞膜上的表达量与结肠癌细胞的侵袭性表型直接相关。最后，HERG 1基因和HERG 1蛋白在原发性结肠直肠癌中均有高比例表达，其中转移癌的发生率最高，而在正常结肠粘膜或腺瘤中均未检测到表达。
The acquisition of the capacity to invade surrounding tissues confers a more malignant phenotype to tumor cells and is necessary for the establishment of metastases. The understanding of the molecular mechanisms underlying cell invasion in human solid tumors such as colorectal cancers could provide not only more sensitive prognostic analyses but also novel molecular targets for cancer therapy.We report in this article that K+ ion channels belonging to the HERG family are important determinants for the acquisition of an invasive phenotype in colorectal cancers. The herg1 gene and HERG1 protein are expressed in many colon cancer cell lines, and the activity of HERG channels modulates colon cancer cell invasiveness. Moreover, the amount of HERG1 protein expressed on the plasma membrane is directly related to the invasive phenotype of colon cancer cells.Finally, both the herg1 gene and HERG1 protein were expressed in a high percentage of primary human colorectal cancers, with the highest incidence occurring in metastatic cancers, whereas no expression could be detected either in normal colonic mucosa or in adenomas.