PRENATAL DEVELOPMENT OF CEREBELLAR SYSTEM IN RAT .1. CYTOGENESIS AND HISTOGENESIS OF DEEP NUCLEI AND CORTEX OF CEREBELLUM
PRENATAL DEVELOPMENT OF CEREBELLAR SYSTEM IN RAT .1. CYTOGENESIS AND HISTOGENESIS OF DEEP NUCLEI AND CORTEX OF CEREBELLUM
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DOI：
10.1002/cne.901790104
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发表时间：
1978-01-01
影响因子：
2.5
通讯作者：
BAYER, SA
中科院分区：
文献类型：
--
作者：
ALTMAN, J;BAYER, SA
用3种方法研究胎儿小脑发育。在正常胚胎切片3平面形态学和细胞学的变化进行了测定，每天的时间间隔开始于胚胎第13天（E13）。一系列类似的X射线照射胚胎被用来研究神经上皮组织的变化和原始（辐射敏感）或分化细胞的位置。采用渐进延迟标记法对不同类型小脑神经元的起源时间进行定量。使用成年大鼠的放射自显影图，这些大鼠的母亲从第E13天开始在重叠的日子连续2次每日注射3 H-胸苷。
Prenatal cerebellar development was investigated with 3 approaches. In normal embryos sectioned in 3 planes morphological and cytological changes were determined at daily intervals beginning on embryonic day 13 (E13). A similar series of X-irradiated embryos was used to study changes in neuroepithelial organization and in the location of primitive (radiosensitive) or differentiated cells. The time of origin of different classes of cerebellar neurons was quantified with the progressively delayed labeling procedure. Autoradiograms from adult rats whose mothers were injected with 2 successive daily doses of 3H-thymidine on overlapping days from day E13 on were used.