Endorectal MR imaging MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: Preliminary experience
Endorectal MR imaging MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: Preliminary experience
复制标题
DOI：
10.1148/radiol.2332032086
复制
发表时间：
2004-11-01
期刊：
影响因子：
19.7
通讯作者：
Kurhanewicz, J
中科院分区：
文献类型：
--
作者：
Coakley, FV;Teh, HS;Kurhanewicz, J
目得：评价直肠内磁共振（MR）成像和MR波谱成像的描述局部复发的前列腺癌后外照射radiationtherapy.MATERIALS和METHODS：直肠内MR成像和MR波谱成像进行了21例生化失败后外照射放射治疗前列腺癌。两名阅片者独立回顾性审查了MR图像，并在五分量表上对肿瘤复发的可能性进行了评分。如果胆碱水平升高且不存在柠檬酸盐，则认为光谱体素疑似恶性肿瘤。受试者工作特征曲线分析用于评估直肠内MR成像和光谱成像在不同阈值下前列腺每侧的癌症检测，这些阈值分别基于两名阅片者分配的评分和每个半侧前列腺中可疑体素的数量。在随后的经直肠活检癌的存在或不存在被用作标准的reference.Results：活检显示局部复发的前列腺癌在9个半前列腺6例。对于读片者1和读片者2，MR成像检测局部复发癌的受试者工作特征曲线下面积分别为0.49和0.51。通过使用可疑体素的数量来定义不同的诊断阈值，MR波谱成像的受试者工作特征曲线下的面积显著（P <0.005）更高，为0.81。特别是，在半侧前列腺中存在三个或更多个可疑体素，诊断局部复发的灵敏度和特异性分别为89%和82%。七个hemiprosts表现出完全的代谢性萎缩在光谱成像和只有postirradiation萎缩在biopsiz.CONCLUSION：初步数据表明，磁共振波谱成像，但不是直肠内磁共振成像，可能是局部复发的前列腺癌放疗后的描述价值。(C)RSNA，2004年。
PURPOSE: To evaluate endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging for the depiction of locally recurrent prostate cancer after external beam radiation therapy.MATERIALS AND METHODS: Endorectal MR imaging and MR spectroscopic imaging were performed in 21 patients with biochemical failure after external beam radiation therapy for prostate cancer. Two readers independently and retrospectively reviewed MR images and rated the likelihood of recurrent tumor on a five-point scale. Spectroscopic voxels were considered suspicious for malignancy if the choline level was elevated and citrate was absent. Receiver operating characteristic curve analysis was used to assess cancer detection in each side of the prostate with endorectal MR imaging and spectroscopic imaging at different thresholds based on the scores assigned by the two readers and on the number of suspicious voxels in each hemiprostate, respectively. The presence or absence of cancer at subsequent transrectal biopsy was used as the standard of reference.RESULTS: Biopsy demonstrated locally recurrent prostate cancer in nine hemiprostates in six patients. The area under the receiver operating characteristic curve for the detection of locally recurrent cancer with MR imaging was 0.49 and 0.51 for readers 1 and 2, respectively. By using the number of suspicious voxels to define different diagnostic thresholds, the area under the receiver operating characteristic curve for MR spectroscopic imaging was significantly (P < .005) higher, at 0.81. In particular, the presence of three or more suspicious voxels in a hemiprostate showed a sensitivity and specificity of 89% and 82%, respectively, for the diagnosis of local recurrence. Seven hemiprostates demonstrated complete metabolic atrophy at spectroscopic imaging and only postirradiation atrophy at biopsy.CONCLUSION: Preliminary data suggest that MR spectroscopic imaging, but not endorectal MR imaging, may be of value for the depiction of locally recurrent prostate cancer after radiation therapy. (C) RSNA, 2004.