Circadian clock regulation of skeletal muscle growth and repair.
Circadian clock regulation of skeletal muscle growth and repair.
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DOI：
10.12688/f1000research.9076.1
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ma K
中科院分区：
文献类型：
--
作者：
Chatterjee S;Ma K
越来越多的证据表明，生物钟，一个转录/翻译反馈电路，产生约24小时的行为和生理振荡，是一个关键的时间调节机制，涉及肌肉生理学的许多重要方面。由于生物钟是一种进化上保守的计时机制，它使内部生理学适应环境线索，骨骼肌发起的运动活动能够参与地球上的明暗循环，从而确保生物体的生存和健康。尽管目前对分子时钟在预防年龄相关性肌肉减少症中的作用的理解，但对传递时钟信号以维持骨骼肌生长和功能的潜在分子途径的研究才刚刚出现。在目前的审查中，肌肉时钟在维持肌肉质量的发展，修复和老化过程中的重要性，以及它对肌肉代谢的贡献，将进行讨论。基于我们目前对组织内在肌肉时钟在肌肉生理学的关键方面如何发挥作用的理解，针对时钟回路的肌源性调节活动的干预可能为预防和治疗肌肉疾病提供新的途径。对骨骼肌生物钟功能和调节机制的研究需要继续努力。
Accumulating evidence indicates that the circadian clock, a transcriptional/translational feedback circuit that generates ~24-hour oscillations in behavior and physiology, is a key temporal regulatory mechanism involved in many important aspects of muscle physiology. Given the clock as an evolutionarily-conserved time-keeping mechanism that synchronizes internal physiology to environmental cues, locomotor activities initiated by skeletal muscle enable entrainment to the light-dark cycles on earth, thus ensuring organismal survival and fitness. Despite the current understanding of the role of molecular clock in preventing age-related sarcopenia, investigations into the underlying molecular pathways that transmit clock signals to the maintenance of skeletal muscle growth and function are only emerging. In the current review, the importance of the muscle clock in maintaining muscle mass during development, repair and aging, together with its contribution to muscle metabolism, will be discussed. Based on our current understandings of how tissue-intrinsic muscle clock functions in the key aspects muscle physiology, interventions targeting the myogenic-modulatory activities of the clock circuit may offer new avenues for prevention and treatment of muscular diseases. Studies of mechanisms underlying circadian clock function and regulation in skeletal muscle warrant continued efforts.