The PCI domain: a common theme in three multiprotein complexes
The PCI domain: a common theme in three multiprotein complexes
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DOI：
10.1016/s0968-0004(98)01217-1
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发表时间：
1998-06-01
影响因子：
13.8
通讯作者：
Bucher, P
中科院分区：
文献类型：
--
作者：
Hofmann, K;Bucher, P
图1代表性PCI域的对齐。仅示出了完整PCI结构域的较保守的C-末端一半。在迭代图谱细化过程中，仅接受与已建立图谱匹配且错误概率P 0.01的序列，并在此处显示。如前所述估计错误概率12。相同的氨基酸残基以黑色背景显示;在至少50%的序列中相似的残基以灰色背景显示。左边的数字表示每个结构域在蛋白质序列中的位置。这些蛋白质的替代名称见表I。序列按生物学功能分组，由左侧的颜色条表示：洋红色，蛋白酶体;绿色，COP 9;青色，eIF 3。比对顶部的红色字母表示预测螺旋的位置8。HS，人; MM，小鼠; SC，酿酒酵母; AT，拟南芥。
Figure 1 Alignment of representative PCI domains. Only the better-conserved C-terminal half of the complete PCI domain is shown. Only sequences matching established profiles with an error probability of P 0.01 were accepted during iterative profile refinement and are shown here. Error probabilities were estimated as described previously12. Identical amino acid residues are shown against a black background; residues that are similar in at least 50% of the sequences are shown against a grey background. Numbers on the left indicate the position of each domain within the protein sequence. Alternative names for these proteins can be found in Table I. The sequences are grouped by biological function, which is indicated by the colour bars on the left: magenta, proteasome; green, COP9; cyan, eIF3. The red letters at the top of the alignment indicate the positions of the predicted-helices8. HS, human; MM, mouse; SC, Saccharomyces cerevisiae; AT, Arabidopsis thaliana.