Characterization of skin dermis microcirculation in flow-mediated dilation using optical sensor with pressurization mechanism
Characterization of skin dermis microcirculation in flow-mediated dilation using optical sensor with pressurization mechanism
复制标题
使用具有加压机制的光学传感器表征流介导扩张中的皮肤真皮微循环
DOI：
10.1007/s11517-012-1017-2
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
N. Taniguchi and T. Miwa
中科院分区：
文献类型：
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作者：
Y. Yamakoshi;K. Kotani;N. Taniguchi and T. Miwa
当对指尖施加高于动脉血压的压力时，血液从真皮中的微血管流出，随后当压力释放时重新流入微循环。加压下微循环的血液流出和回流特性都与微血管、血液和血压有关。本研究描述了一种测量真皮微循环血液流入和流出特性的新方法。使用高于人类受试者的收缩动脉压的压力将配备有571 nm波长光源和光电检测器的光学传感器按压到皮肤表面。根据Beer-Lambert定律，通过血流量的变化来估计血红蛋白浓度。应用该方法测定了缺血5 min后反应性充血引起的微循环血流流入和流出特性。在评价的三个参数中，与脉动幅度相关的一个显示出与常规体积描记法的密切相关性，而另外两个显示出不同的时间响应。我们的方法为健康和疾病状况的病理生理学提供了一个新的有用的见解，可以帮助研究人员更好地了解许多微循环影响的疾病和医疗条件的潜在机制。
Blood flows out of microvessels in the dermis when pressure higher than arterial blood pressure is applied to the fingertip, and subsequently re-flows into the microcirculation when pressure is released. Both the blood outflow and the reflow characteristics of microcirculation under pressurization are associated with microvasculature, blood and blood pressure. This study describes a novel method of measuring blood inflow and outflow characteristics of dermis microcirculation. An optical sensor, which is furnished with a 571 nm wavelength light source and a photodetector, is pressed to the skin surface using a pressure higher than the human subject’s systolic arterial pressure. Hemoglobin concentration by change of the blood flow amount is estimated by the Beer–Lambert law. This method is applied to the measurement of blood inflow and outflow characteristics of microcirculation caused by reactive hyperemia after ischemia with duration of 5 min. Among three parameters evaluated, the one relating to the amplitude of pulsation shows a close correlation with conventional plethysmography, while the other two show varying time responses. Our method provides a new and useful insight into pathophysiology in health and disease conditions and may help researchers better understand the underlying mechanisms of numerous microcirculation-influenced diseases and medical conditions.