Selective activation and deactivation of the human brain structures between speeded and precisely timed tapping responses to identical visual stimulus: an fMRI study
Selective activation and deactivation of the human brain structures between speeded and precisely timed tapping responses to identical visual stimulus: an fMRI study
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DOI：
10.1016/j.neuroimage.2004.03.043
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发表时间：
2004-07-01
期刊：
影响因子：
5.7
通讯作者：
Ohtsuki, T
中科院分区：
文献类型：
--
作者：
Kudo, K;Miyazaki, M;Ohtsuki, T
我们使用功能磁共振成像研究了大脑活动对相同视觉刺激的快速反应和精确定时反应之间的差异。使用的刺激是一排七个发光二极管（LED），在试验中以恒定的速度依次点亮，但在试验之间以不同的速度发光。要求受试者用右手进行手指-拇指敲击，以响应反应时间 (RT) 任务中第一个 LED 灯的出现，并预期计时任务中最后一个（即第七个）LED 灯的出现。在控制条件下，他们被要求被动地观察刺激而没有运动反应。结果表明，包括对侧扣带运动皮层在内的各种运动相关区域在相对于控制条件的这两项任务中通常被激活，这表明这些结构涉及一般感知和响应执行，而不是快速或精确定时响应的特定功能。在 RT 任务中，延伸至扣带沟的前补充运动区被激活。比计时任务更强烈的可能是将注意力集中在随机前段后不可预测地出现的第一个 LED 灯的出现上。延伸到颞顶枕交界处的枕外侧区在计时任务中比在 RT 任务中被激活得更强烈；相对于控制条件，RT 任务中同一区域被停用。这两项任务中与听觉相关的区域也被停用。这种模式间和模式内特定任务的修改（包括停用）强调了感知和行动的背景重要性，并且可以在灵巧或熟练的表现中发挥重要作用。 (C) 2004 Elsevier Inc. 保留所有权利。
We investigated the difference, between brain activities in speeded and precisely timed responses to identical visual stimulus using fMRI. Stimulus used was a row of seven light-emitting diodes (LEDs) lightened up one after another with constant speed within a trial but with various speeds between trials. Subjects were asked to execute finger-thumb tapping with the right hand in response to the onset of the first LED light in the reaction time (RT) task and in anticipation of the onset of the last (i.e., seventh) LED light in the timing task. In control condition, they were asked to passively view the stimulus without motor response. Results showed that various movement-related areas including contralateral cingulate motor cortex were commonly activated for both tasks relative to the control condition, suggesting these structures are involved in general perception and response execution rather than specific function for speeded or precisely timed responses. In the RT task, the presupplementary motor area extending to the cingulate sulcus was activated. more strongly than in the timing task probably to focus attention to the onset of the first LED light unpredictably presented after random foreperiods. The lateral occipital area extending to the temporo-parieto-occipital junction was activated more strongly in the timing task than in the RT task; the same area was deactivated in the RT task relative to the control condition. Auditory-related areas were also deactivated in the both tasks. This inter- and intramodal task-specific modification including deactivation underscores significance of the context for perception and action and can have an important role in dexterous or skilled performance. (C) 2004 Elsevier Inc. All rights reserved.