RELATIVE EFFECTS OF DIETARY SATURATED, MONOUNSATURATED, AND POLYUNSATURATED FATTY-ACIDS ON CARDIAC-ARRHYTHMIAS IN RATS
RELATIVE EFFECTS OF DIETARY SATURATED, MONOUNSATURATED, AND POLYUNSATURATED FATTY-ACIDS ON CARDIAC-ARRHYTHMIAS IN RATS
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DOI：
10.1093/ajcn/57.2.207
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发表时间：
1993-02-01
影响因子：
7.1
通讯作者：
MCLENNAN, PL
中科院分区：
文献类型：
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作者：
MCLENNAN, PL
本研究比较了单不饱和油酸与 n-6 和 n-3 多不饱和脂肪酸 (PUFA) 改变大鼠缺血或再灌注期间心律失常脆弱性的能力。用富含油酸的橄榄油替代饮食中的饱和动物脂肪并没有显着改变心室颤动或其他心律失常的发生率。用富含 n-6 的葵花籽油或富含 n-3 的鱼油替代可降低缺血时心律失常的发生率和严重程度。鱼油显着减少再灌注心律失常，与先前的缺血性心律失常无关。与饱和脂肪（42%；n = 24）相比，n-6（8%；n = 25）和 n-3（0%；n = 24）PUFA 显着降低致命性心室颤动，但单不饱和脂肪酸（36%；n = 25）则没有显着降低致命性心室颤动。结果表明，用 n-6 尤其是 n-3 PUFA（而不是单不饱和脂肪酸）替代饮食中的饱和脂肪可以降低导致心源性猝死的缺血事件的可能性。
This study compared monounsaturated oleic acid with n-6 and n-3 polyunsaturated fatty acids (PUFAs) for their ability to modify the vulnerability to cardiac arrhythmias during ischemia or reperfusion in rats. Replacement of saturated animal fat in the diet with oleic acid-rich olive oil did not significantly alter the incidence of ventricular fibrillation or other cardiac arrhythmias. Replacement with either n-6-rich sunflower seed oil or n-3-rich fish oil reduced the incidence and severity of arrhythmias occurring in ischemia. The fish oil significantly reduced reperfusion arrhythmias independently of antecedent ischemic arrhythmias. Fatal ventricular fibrillation was significantly reduced by n-6 (8%; n = 25) and n-3 (0%; n = 24) PUFA but not by monounsaturates (36%; n = 25) compared with saturated fat (42%; n = 24). The results suggest that dietary replacement of saturated fats by n-6 and especially n-3 PUFA but not monounsaturated fatty acids can reduce the likelihood of an ischemic event leading to sudden cardiac death.