Danger and safety signals independently influence persistent pathological avoidance in anxiety-vulnerable Wistar Kyoto rats: A role for impaired configural learning in anxiety vulnerability.
Danger and safety signals independently influence persistent pathological avoidance in anxiety-vulnerable Wistar Kyoto rats: A role for impaired configural learning in anxiety vulnerability.
复制标题
危险和安全信号独立影响焦虑易感 Wistar京都大鼠的持续病理性回避：配置学习受损在焦虑脆弱性中的作用。
DOI：
10.1016/j.bbr.2018.07.025
复制
发表时间：
2019
影响因子：
2.7
通讯作者：
Pang,KevinCH
中科院分区：
文献类型：
--
作者：
Spiegler,KevinM;Smith,IanM;Pang,KevinCH
焦虑和焦虑相关疾病中的病理性回避行为在疾病的持续性和严重性中起着重要作用。个体通过学习环境中的危险和安全信号来避免潜在的厌恶事件。与那些没有这些疾病的人相比，焦虑症患者表现出更多地利用危险信号而不是安全信号的偏见。因此，本研究调查，如果危险和安全信号差异影响持续回避的焦虑脆弱性的动物模型，Wistar京都（WKY）大鼠，相对于远交的Sprague道利（SD）大鼠。使用消退方案评估持续回避。当灭绝过程中存在危险或安全信号时，WKY大鼠比SD大鼠更慢地熄灭回避反应。相反，当灭绝过程中存在危险和安全信号时，WKY和SD大鼠以相似的速度灭绝。背景学习和配置学习的差异被探索为避免灭绝中使用安全和危险信号的紧张差异的潜在原因。当操纵上下文时，菌株在回避灭绝方面没有差异。然而，WKY大鼠在使用消极模式任务的图形学习中受损。结果表明，危险和安全信号可能会损害回避灭绝的焦虑脆弱的个人，由于受损的神经学习。这些发现对于理解焦虑症的病因具有重要意义，并可能改善其诊断和治疗。
Pathological avoidance behavior in anxiety and anxiety-related disorders has a large role in the persistence and severity of disease. Individuals are cued to avoid potential aversive events by learned danger and safety signals in the environment. Individuals with anxiety demonstrate a bias to utilize danger signals more than safety signals, in contrast to those without these disorders. Therefore, the present study investigated if danger and safety signals differentially influenced persistent avoidance in an animal model of anxiety-vulnerability, the Wistar Kyoto (WKY) rat, relative to the outbred Sprague Dawley (SD) rat. Persistent avoidance was assessed using extinction protocols. When danger or safety signals were present during extinction, WKY rats were slower to extinguish the avoidance response compared to SD rats. In contrast, when danger and safety signals were both present during extinction, WKY and SD rats extinguished at a similar rate. Differences in contextual and configural learning were explored as potential causes of the strain differences in the use of safety and danger signals in avoidance extinction. Strains did not differ in avoidance extinction when context was manipulated. However, WKY rats were impaired in configural learning using a negative patterning task. The results indicate that danger and safety signals may impair avoidance extinction in anxiety-vulnerable individuals due to impaired configural learning. These findings have important implications for understanding the etiology of anxiety disorders and may improve their diagnosis and treatment.