Epidemiology and Clinical Presentation of Children Hospitalized with SARS-CoV-2 Infection in Suburbs of Paris
Epidemiology and Clinical Presentation of Children Hospitalized with SARS-CoV-2 Infection in Suburbs of Paris
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DOI：
10.3390/jcm9072227
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发表时间：
2020-07-01
影响因子：
3.9
通讯作者：
Madhi, Fouad
中科院分区：
文献类型：
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作者：
Gaborieau, Louise;Delestrain, Celine;Madhi, Fouad
了解儿童严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染的临床表现和预后是一个重大问题。儿童往往表现出轻微的症状，一些严重的形式需要儿科重症监护，在某些情况下，预后致命。我们的目的是确定在巴黎郊区医院住院的2019冠状病毒病（Covid-19）儿童的流行病学特征、临床表现和预后。在这项前瞻性、观察性、多中心研究中，我们纳入了2020年3月23日至2020年5月10日法国全国封锁期间在巴黎郊区医院儿科住院的确诊SARS-CoV-2感染的儿童（鼻咽拭子RNA检测阳性）或高度疑似感染（提示SARS-CoV-2感染的临床、生物学和/或放射学数据特征）。共有192名儿童被纳入确诊（n= 157）或高度疑似（n= 35）SARS-CoV-2感染。中位年龄为1岁（四分位数间距为0.125-11），性别比为1.3：1。147例（76.6%）儿童出现发热，29例（15.1%）耐受不良。症状包括腹泻（34.4%）、胃肠道（35.5%）和呼吸窘迫（25%）。只有10名（5.2%）儿童有嗅觉丧失，5名（2.6%）有胸痛。在我们的研究中，近30%的儿童被发现患有潜在疾病。总体而言，24名（12.5%）儿童被送入儿科重症监护室，12名需要机械通气，3名死亡。对于巴黎郊区的儿童来说，大多数新冠肺炎病例表现出轻度或中度的临床表现。然而，八分之一的儿童被送进儿科重症监护室，三名儿童死亡。
Understanding the clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and prognosis in children is a major issue. Children often present mild symptoms, and some severe forms require paediatric intensive care, with in some cases a fatal prognosis. Our aim was to identify the epidemiological characteristics, clinical presentation, and prognosis of children with coronavirus disease 2019 (Covid-19) hospitalized in Paris suburb hospitals. In this prospective, observational, multicentre study, we included children hospitalized in paediatric departments of Paris suburb hospitals from 23 March 2020 to 10 May 2020, during the national lockdown in France with confirmed SARS-CoV-2 infection (positive RNA test on a nasopharyngeal swab) or highly suspected infection (clinical, biological, and/or radiological data features suggestive for SARS-CoV-2 infection). A total of 192 children were included for confirmed (n= 157) or highly suspected (n= 35) SARS-CoV-2 infection. The median age was one year old (interquartile range 0.125-11) with a sex ratio 1.3:1. Fever was recorded in 147 (76.6%) children and considered poorly tolerated in 29 (15.1%). The symptoms ranged from rhinorrhoea (34.4%) and gastrointestinal (35.5%) to respiratory distress (25%). Only 10 (5.2%) children had anosmia and five (2.6%) had chest pain. An underlying condition was identified in almost 30% of the children in our study. Overall, 24 (12.5%) children were admitted to paediatric intensive care units, 12 required mechanical ventilation, and three died. For children in Paris suburbs, most cases of Covid-19 showed mild or moderate clinical expression. However, one-eighth of children were admitted to paediatric intensive care units and three died.