Thiopentone induced coma after severe birth asphyxia.
Thiopentone induced coma after severe birth asphyxia.
复制标题
严重出生窒息后硫喷妥钠引起昏迷。
DOI：
10.1136/adc.61.11.1084
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发表时间：
1986
影响因子：
5.2
通讯作者：
A. Wilkinson
中科院分区：
文献类型：
--
作者：
J. Eyre;A. Wilkinson
本研究的目的是确定通过输注大剂量硫喷妥钠诱导严重窒息新生儿长时间昏迷的可行性。对6例重度窒息儿进行连续脑电图和血压监测。以足以完全抑制EEG的速率输注硫喷妥钠，前提是平均血压保持在35 mm Hg以上;持续输注硫喷妥钠直至24小时内无脑水肿迹象。在2例患者中，由于对治疗无反应的低血压而提前停止输注。在其他四名患者中，深度昏迷的平均持续时间为127小时。所有开发的药效学耐受硫喷妥钠，并显示非线性消除动力学。三名婴儿死亡;三名幸存者有中度至重度残疾。得出的结论是，在充分的重症监护下，有可能引起深度昏迷;然而，结局似乎没有改善，并发症的发生率很高。
The aim of this study was to determine the feasibility of inducing a prolonged coma in severely asphyxiated newborn babies by the infusion of high dose thiopentone. In six severely asphyxiated babies the electroencephalograph (EEG) and blood pressure were monitored continuously. Thiopentone was infused at a rate sufficient to suppress completely the EEG providing the mean blood pressure remained above 35 mm Hg; it was continued until there was no evidence of cerebral oedema for 24 hours. In two the infusion was stopped prematurely because of hypotension that was unresponsive to treatment. In the other four a deep coma was maintained for a median duration of 127 hours. All developed pharmacodynamic tolerance to the thiopentone and showed non-linear elimination kinetics. Three babies died; the three survivors have moderate to severe handicap. It was concluded that with full intensive care it is possible to induce a deep coma; the outcome does not seem to be improved, however, and the incidence of complications was high.