CARCINOGENESIS AND AGING .3. THE ROLE OF AGE IN INITIATION AND PROMOTION OF CARCINOGENESIS
CARCINOGENESIS AND AGING .3. THE ROLE OF AGE IN INITIATION AND PROMOTION OF CARCINOGENESIS
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DOI：
10.1016/s0232-1513(82)80001-7
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
ANISIMOV, VN
中科院分区：
文献类型：
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作者：
ANISIMOV, VN
从致癌作用的2阶段模型的角度讨论了致癌作用与衰老之间的相互关系问题。关于s.c.致癌作用的数据。给药苯并（a）芘（BP），阴道内应用7，12-二甲基苯并（a）蒽（DMBA）和静脉注射N-亚硝基甲基脲（NMU）的年轻和老年动物[小鼠，大鼠]。从现有文献中获得的结果和数据都表明，年龄对致癌作用没有统一的影响。致癌物代谢酶活性的生物学相关动力学，DNA修复的准确性和靶组织和非靶组织的增殖活性作为观察到的差异的决定性因素进行了讨论。还提供了一些可移植肿瘤在年轻和年老动物中的生长速率的数据。通常，上述肿瘤在老年动物中比在年轻动物中生长得更快。年龄相关的激素，代谢和免疫学的变化在肿瘤促进的作用进行了讨论。强调了在自然衰老和致癌过程中，在有机体、组织和细胞整合水平上发生的一些变化的相似性。本文综述了近年来有关抗衰老药物对自发性癌变作用的研究结果。老年保护剂，这被证明是延迟衰老和年龄病理学发展的遗传程序的实现，延长寿命和抑制癌变比那些影响自发癌变的初始阶段更有效。提出了癌变过程中细胞、组织和生物体发生事件的整体图式。
The problem of an interrelation between carcinogenesis and aging is discussed from the point of view of the 2-stage model of carcinogenesis. Data on the carcinogenic effect of s.c. administered benzo(a)pyrene (BP), intravaginally applied 7,12-dimethylbenz(a)anthracene (DMBA) and i.v. injected N-nitrosomethylurea (NMU) to young and old animals [mouse, rat] are presented. Both the obtained results and data from available literature show the absence of a uniform effect of age on carcinogenesis. Age-associated dynamics of carcinogen-metabolizing enzyme activity, accuracy in DNA repair and proliferative activity of target and non-target tissues were discussed as the determinant factors for observed differences. Data on the growth rate of some transplantable tumors in young and old animals are also presented. As a rule, the above tumors grow more rapidly in old animals in comparison with young ones. The role of age-associated hormonal, metabolic and immunological changes in tumor promotion is discussed. The similarity of a number of changes occurring at organism, tissue and cellular levels of integration during natural aging and carcinogenesis is stressed. Some results of study on effects of geroprotectors on spontaneous carcinogenesis are summarized. The geroprotectors, which were shown to delay the realization of the genetic program of aging and age pathology development, prolong lifespan and inhibit carcinogenesis more effectively than those influencing the initial stage of spontaneous carcinogenesis. The integral scheme of events taking place in cell, tissue and organism during carcinogenesis is presented.