Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat
Involvement of histaminergic neurons in arousal mechanisms demonstrated with H3-receptor ligands in the cat
复制标题
DOI：
10.1016/0006-8993(90)91508-e
复制
发表时间：
1990-07
期刊：
影响因子：
2.9
通讯作者：
Jian-Sheng Lin;K. Sakai;G. Vanni-Mercier;J. Arrang;M. Garbarg;J. Schwartz;M. Jouvet
中科院分区：
文献类型：
--
作者：
Jian-Sheng Lin;K. Sakai;G. Vanni-Mercier;J. Arrang;M. Garbarg;J. Schwartz;M. Jouvet
研究了组胺H3受体配体对自由活动猫睡眠觉醒参数的影响。口服H3受体激动剂(R)-甲基组胺(α-α，MHA)可显著增加大鼠的慢波深度睡眠，而H3受体拮抗剂硫代巴比妥钠则显著增强觉醒，且呈剂量依赖关系。预先给予α、MHA或H1受体拮抗剂美拉明可阻断硫代巴比妥钠的唤醒作用。这些发现支持组胺能神经元在唤醒机制中起关键作用的假设，并表明H3受体通过调节组胺传递在这些机制中发挥积极作用。
The effects of histamine H3-receptor ligands on sleep-waking parameters were studied in freely moving cats. Oral administration of (R)α-methylhistamine (αMHA), a H3-agonist, caused a significant increase in deep slow wave sleep while that of thioperamide, a H3-antagonist, enhanced wakefulness in a marked and dose-dependent manner. The arousal effects of thioperamide were prevented by pretreatment with αMHA or mepyramine, a H1-receptor antagonist. The findings support the hypothesis that the histaminergic neurons are critically involved in arousal mechanisms and suggest that H3-receptors play an active part in these mechanisms by regulating histamine transmission.