Modeling Approach for An Aortic Dissection with Endovascular Stenting
Modeling Approach for An Aortic Dissection with Endovascular Stenting
复制标题
血管内支架主动脉夹层建模方法
DOI：
10.1109/embc44109.2020.9176423
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hanzawa K
中科院分区：
文献类型：
--
作者：
Shiraishi Y;Yambe T;Narracott AJ;Yamada A;Morita R;Qian Y;Hanzawa K
主动脉夹层的修复需要重建中膜结构。已经报告了针对主动脉夹层血管内支架植入术的建模方法。我们建立了山羊降主动脉夹层模型，并在模拟循环系统中复制了其形态学特征。本研究的目的是从生物医学血流动力学的角度来检查一种新开发的能够安装到主动脉夹层病变的主动脉支架。在这项研究中，我们检查了夹层病变的血流动力学变化和血管内支架介入治疗的改善。首先，我们进行了动物实验与夹层主动脉瓣和检查的影响，支架的体积变化的假腔。其次，我们制作了几种不同类型的主动脉夹层模型，并在假腔和真腔之间放置硅橡胶膜。然后，在模拟循环系统中的脉动流条件下评价每个模型中的血流动力学特性。这些建模方法能够定量检查支架植入术的治疗后效应，然后阐明支架附近的血流动力学变化，这可能遵循主动脉支架植入术介入治疗的临床改善管理。
Repair of dissected aorta requires remodeling the structure of the media. Modeling approaches specific to endovascular stenting for aortic dissection have been reported. We created a goat model of descending thoracic aortic dissection and reproduced its morphological characteristics in a mock circulatory system. The purpose of this study was to examine a newly developed aortic stent which was capable of installing to the aortic dissected lesion for biomedical hemodynamics point of view. In this study, we examined the changes in hemodynamics of dissected lesions and the amelioration by endovascular stent intervention. Firstly, we performed animal experiments with the dissected aorta and examined the effects of stenting on volumetric changes in the false lumen. Secondly, we made several types of 3-D stereolithographic dissected aortic models with silicone rubber membrane between the false and the true lumens. Then, the hemodynamic characteristics in each model were evaluated in the pulsatile flow conditions in a mock circulatory system. These modelling approaches enabled the quantitative examination of post-therapeutic effects of stenting followed by elucidating of hemodynamic changes in the vicinity of stents, which may follow the management of clinical amelioration of interventional treatment with aortic stenting.