ZIKA VIRUS INFECTION OF CENTRAL NERVOUS SYSTEM OF MICE
ZIKA VIRUS INFECTION OF CENTRAL NERVOUS SYSTEM OF MICE
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DOI：
10.1007/bf01249709
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发表时间：
1971-01-01
期刊：
影响因子：
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通讯作者：
NARANG, HK
中科院分区：
文献类型：
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作者：
BELL, TM;FIELD, EJ;NARANG, HK
新生和5周大的小鼠脑内接种寨卡病毒后，星形胶质细胞早期显著增大，阿蒙角梨形细胞呈片状破坏。病毒在神经元和星形胶质细胞中都有复制。内质网内似乎形成了新的病毒粒子。这些超微结构的观察结果与其他B组虫媒病毒活体研究的结果相似，与体外研究的结果大相径庭。
Intracerebral inoculation of newborn and 5-week-old mice with Zika virus resulted in an early and marked enlargement of astroglial cells with patchy destruction of the pyriform cells of Ammon's horn. Replication of the virus was demonstrated in both neurones and astroglial cells. New virions appeared to be formed within networks of endoplasmic reticulum. The similarity of these ultrastructural observations to those obtained fromin vivostudies of other group B arboviruses is contrasted with the widely differing findings fromin vitrostudies.