Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma.
Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma.
复制标题
DOI：
--
复制
发表时间：
1991-09
期刊：
影响因子：
11.2
通讯作者：
R. Harning;E. Mainolfi;J. Bystryn;M. Henn;V. J. Merluzzi;R. Rothlein
中科院分区：
文献类型：
--
作者：
R. Harning;E. Mainolfi;J. Bystryn;M. Henn;V. J. Merluzzi;R. Rothlein
目前的报道表明细胞内粘附分子1（ICAM-1）在人类恶性黑色素瘤和其他癌症的进展中的作用。组织学诊断为恶性黑色素瘤的I、II和III期患者血清循环ICAM-1（cICAM-1）水平显著升高，阳性血清发生率显著增加。在II期和III期患者中，cICAM-1水平与生存率呈负相关。血清cICAM-1水平升高（高于对照平均值2个SD单位）的患者平均生存期显著缩短。我们认为血清cICAM-1水平升高可能对恶性皮肤黑色素瘤患者的诊断和预后具有重要意义。
Current reports have suggested a role for intracellular adhesion molecule 1 (ICAM-1) in the progression of human malignant melanoma and other cancers. Stage I, II, and III patients with histologically diagnosed malignant melanoma had significantly increased serum levels of circulating ICAM-1 (cICAM-1) and a striking increase in the incidence of positive sera. In Stage II and III patients, the level of cICAM-1 was inversely correlated with survival. Patients with elevated levels of serum cICAM-1 (greater than 2 SD units above control mean) had a significantly shorter mean survival. We suggest that elevated levels of serum cICAM-1 may be of diagnostic and prognostic importance in patients with malignant cutaneous melanoma.