Gadolinium-based contrast agents and nephrotoxicity in patients undergoing coronary artery procedures
Gadolinium-based contrast agents and nephrotoxicity in patients undergoing coronary artery procedures
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DOI：
10.1002/ccd.20592
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发表时间：
2006-02-01
影响因子：
2.3
通讯作者：
Ricciardelli, B
中科院分区：
文献类型：
--
作者：
Briguori, C;Colombo, A;Ricciardelli, B
目的：我们测试了基于Gd的造影剂是否比碘化造影剂的肾毒性小。背景：放射性造影剂具有肾毒性。一些数据表明，与加碘的造影剂相比，基于Gd的造影剂对肾脏的毒性可能较小。方法：25例慢性肾功能不全患者(肌酐浓度和/或清除率均为2.0 mg/dl和/或清除率0.05)。术后48小时肌酐浓度升高至少0.50 mg/dl的患者中有7/25例(28%)，而碘化组中2/32例(6.5%)(P=0.034；OR=4.48；95%CI=1.01-19.17)。2例(8%)患者发生肾功能衰竭需要临时透析，而碘化组无一例发生肾功能衰竭(P=0.19)。结论：在慢性肾功能不全的患者中，与碘化等渗造影剂相比，基于Gd的造影剂给药策略似乎并不能降低CAN的发生率。(C)2006年Wiley-Liss，Inc.
Objective: We tested whether gadolinium-based contrast agent is less nephrotoxic than iodinated-contrast media. Background: lodinated contrast agents are nephrotoxic. Some data suggest that gadolinium-based contrast agent may be less nephrotoxic than iodinated-contrast media. Methods: Twenty-five consecutive patients with chronic renal insufficiency (creatinine concentration >= 2.0 mg/dl and/or clearance 0.05 for all). Increase of at least 0.5 mg/dl of the creatinine concentration 48 hr after the procedure occurred in 7/25 (28%) patients in the Gadolinium-based group and in 2/32 (6.5%) patients in the lodinated-based group (P = 0.034; OR = 4.48; 95% CI = 1.01-19.17). Renal failure requiring temporary dialysis occurred in 2 (8%) patients in the Gadolinium-based group and in none in the lodinated-based group (P = 0.19). Conclusions: The strategy of gadolinium-based contrast agent administration does not seem to reduce the rate of CAN, as compared to the iodinated iso-osmolality contrast agent inpatients with chronic renal insufficiency. (c) 2006 Wiley-Liss, Inc.