Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolates.
Molecular epidemiology of the fsr locus and of gelatinase production among different subsets of Enterococcus faecalis isolates.
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粪肠球菌分离株不同亚群中 fsr 位点和明胶酶产生的分子流行病学。
DOI：
10.1128/jcm.42.5.2317-2320.2004
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发表时间：
2004
影响因子：
9.4
通讯作者：
Murray,BarbaraE
中科院分区：
文献类型：
--
作者：
Roberts,JillC;Singh,KavindraV;Okhuysen,PabloC;Murray,BarbaraE
我们检测了215株粪肠球菌，发现两组分调节位点（E. faecalisregulator），也没有明胶酶的产生在疾病相关的分离株中比在健康个体中定殖的分离株中更常见（ca. 60%至65%）。大多数明胶酶阴性分离株，包括14个心内膜炎分离株（共检测80个分离株），含有先前描述的23.9 kb缺失和缺失fsrA和fsrB。这些结果表明，E.尽管明胶酶可能会导致感染，但这项研究并没有像在动物模型中那样解决明胶酶是否会影响疾病的严重程度。
We examined 215Enterococcus faecalisisolates and found that neither the two-component regulatory locusfsr(E. faecalisregulator) nor gelatinase production was more common in disease-associated isolates than in isolates colonizing healthy individuals (ca. 60 to 65%). The majority of gelatinase-negative isolates, including 14 endocarditis isolates (of 80 isolates tested), contained the previously described 23.9-kb deletion and lackedfsrAandfsrB. While these findings indicate that neitherfsrnor gelatinase is required forE. faecalisto cause infection, this study did not address whetherfsror gelatinase affects the severity of disease, as it does in animal models.