SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence.
SARS-CoV-2 Infectivity and Severity of COVID-19 According to SARS-CoV-2 Variants: Current Evidence.
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DOI：
10.3390/jcm10122635
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发表时间：
2021-06-15
影响因子：
3.9
通讯作者：
Gautret P
中科院分区：
文献类型：
--
作者：
Dao TL;Hoang VT;Colson P;Lagier JC;Million M;Raoult D;Levasseur A;Gautret P
背景资料：本文综述了病毒变异与SARS-CoV-2感染性以及COVID-19严重程度之间的关系。方法：通过文献检索（截至2021年5月31日）在PubMed、Web of Science和Google Scholar中识别文章。结果：共纳入63项研究。迄今为止，大多数研究表明，病毒突变，特别是D 614 G变异，与比野生型病毒更高的感染性相关。然而，病毒突变和疾病严重程度之间的关联的证据是缺乏的。一个382个核苷酸缺失的SARS-CoV-2变异体与患者中较轻的感染有关。11，083 G> U突变与无症状患者显著相关。相比之下，ORF 1ab 4715 L和S蛋白614 G变异在报告高死亡率的国家的患者中更常见。目前的证据表明，令人关切的变异导致传染性增加和流行病情况恶化。然而，这种变异与COVID-19感染严重程度之间的关系是矛盾的。结论：COVID-19疫情继续在全球蔓延。有必要预测大的临床队列来评估SARS-CoV-2突变体的毒力和传播性。
Background: We conducted this review to summarize the relation between viral mutation and infectivity of SARS-CoV-2 and also the severity of COVID-19 in vivo and in vitro. Method: Articles were identified through a literature search until 31 May 2021, in PubMed, Web of Science and Google Scholar. Results: Sixty-three studies were included. To date, most studies showed that the viral mutations, especially the D614G variant, correlate with a higher infectivity than the wild-type virus. However, the evidence of the association between viral mutation and severity of the disease is scant. A SARS-CoV-2 variant with a 382-nucleotide deletion was associated with less severe infection in patients. The 11,083G > U mutation was significantly associated with asymptomatic patients. By contrast, ORF1ab 4715L and S protein 614G variants were significantly more frequent in patients from countries where high fatality rates were also reported. The current evidence showed that variants of concern have led to increased infectivity and deteriorating epidemiological situations. However, the relation between this variant and severity of COVID-19 infection was contradictory. Conclusion: The COVID-19 pandemic continues to spread worldwide. It is necessary to anticipate large clinical cohorts to evaluate the virulence and transmissibility of SARS-CoV-2 mutants.
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DOI：
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发表时间：
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DOI：
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发表时间：
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影响因子：
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