A comparison of disrupted sleep patterns in women with cancer-related fatigue and postmenopausal women without cancer.
A comparison of disrupted sleep patterns in women with cancer-related fatigue and postmenopausal women without cancer.
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患有癌症相关疲劳的女性和未患癌症的绝经后女性睡眠模式中断的比较。
DOI：
10.1016/j.ejon.2010.10.003
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Yarandi,Hossein
中科院分区：
文献类型：
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作者：
Wu,Horng-Shiuann;Davis,JeanE;Padiyar,JosnaP;Yarandi,Hossein
疲劳和睡眠中断通常并存，两者都是影响生活质量的癌症突出临床问题。睡眠模式中断可能与癌症相关的疲劳有关。这种关系需要进一步研究。本研究旨在描述和比较接受化疗的疲劳乳腺癌患者与无癌症史的绝经后妇女的睡眠模式。焦虑水平也examined.METHODSData二次分析来自两项研究。采用匹兹堡睡眠质量指数（PSQI）和状态-特质焦虑量表对30名疲劳的乳腺癌化疗患者和32名非癌症绝经后妇女的睡眠质量和状态焦虑进行自评（M=54.3，SD=49.2min）和频繁的夜间觉醒，尽管40%的患者每周使用三次或更多次睡眠药物。与非癌症对照组相比，疲劳患者报告睡眠潜伏期显著延长（p=0.041），更多使用睡眠药物（p=0.006）和更高的PSQI总分（p=0.005）。状态焦虑水平没有显着差异两组（p=0.88）。CONCLUSIONSSTABILITY是在疲劳的乳腺癌妇女接受化疗中断。几乎所有疲劳患者（97%）都有睡眠问题（总体PSQI评分>5），表明这些患者的整体睡眠质量存在显著困难。了解癌症患者睡眠中断的性质可能有助于CRF症状管理，从而制定旨在改善癌症患者睡眠质量的定制干预措施，从而管理疲劳并改善生活质量。
PURPOSEFatigue and disrupted sleep often coexist and both are prominent clinical problems in cancer affecting quality of life. Disrupted sleep patterns are likely related to cancer-related fatigue. The relationship needs further investigation. This study aimed to characterize and compare disrupted sleep patterns in fatigued breast cancer patients receiving chemotherapy with postmenopausal women without a history of cancer. Anxiety levels were also examined.METHODSData for this secondary analysis came from two studies. Global sleep quality and state anxiety were self-reported by 30 fatigued female breast cancer chemotherapy outpatients and 32 non-cancer postmenopausal women using Pittsburgh Sleep Quality Index (PSQI) and State-Trait Anxiety Inventory, respectively.RESULTSFatigued breast cancer patients showed significant sleep difficulties, characterized by prolonged sleep onset latency (M=54.3, SD=49.2min) and frequent nighttime awakenings, despite 40% of the patients using sleep medications three or more times a week. Compared to the non-cancer comparison group, fatigued patients reported significantly longer sleep latency (p=0.041), more use of sleep medications (p=0.006), and higher total PSQI scores (p=0.005). State anxiety levels did not differ between the two groups (p=0.88).CONCLUSIONSSleep is disrupted in fatigued breast cancer women undergoing chemotherapy. Nearly all fatigued patients (97%) had trouble sleeping (global PSQI scores>5), indicating significant difficulties in overall sleep quality among those patients. Knowledge of the nature of sleep disruption among cancer patients may contribute to CRF symptom management leading to tailored interventions designed to improve sleep quality in cancer patients thereby managing fatigue and improving quality of life.