NTRK fusions in osteosarcoma are rare and non-functional events
NTRK fusions in osteosarcoma are rare and non-functional events
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DOI：
10.1002/cjp2.158
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发表时间：
2020-02-05
影响因子：
4.1
通讯作者：
Baumhoer, Daniel
中科院分区：
文献类型：
--
作者：
Ameline, Baptiste;Saba, Karim H.;Baumhoer, Daniel
神经营养酪氨酸受体激酶（NTRK）融合物是一种很有前途的分子靶点，已经在广泛的恶性肿瘤中被描述。融合通常导致嵌合蛋白的表达与组成型酪氨酸激酶激活，驱动肿瘤发生。尽管大多数实体瘤(
Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a low prevalence among most solid tumours (