VISUAL RECEPTIVE-FIELD ORGANIZATION AND CORTICO-CORTICAL CONNECTIONS OF THE LATERAL INTRAPARIETAL AREA (AREA LIP) IN THE MACAQUE
VISUAL RECEPTIVE-FIELD ORGANIZATION AND CORTICO-CORTICAL CONNECTIONS OF THE LATERAL INTRAPARIETAL AREA (AREA LIP) IN THE MACAQUE
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DOI：
10.1002/cne.902990404
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发表时间：
1990-09-22
影响因子：
2.5
通讯作者：
STONER, GR
中科院分区：
文献类型：
--
作者：
BLATT, GJ;ANDERSEN, RA;STONER, GR
研究了食蟹猴顶下小叶外侧岸的视区--外侧顶内区（LIP区）的视感受野生理和解剖联系。顶内沟内侧组5区神经元的传入输入和生理特性（即，面积PEa）也被确定。LIP区由两个脊髓结构区组成：腹侧区（LIPv），其是密集的髓鞘，和邻近视觉区7a的轻度髓鞘背侧区（LIPd）。我们实验室以前的单单位记录研究已经表征了LIP区域神经元的视觉特性，包括许多具有强大的扫视相关活动的神经元。在本研究的第一部分中，使用单单位记录来绘制来自LIP的两个脊髓结构区中的神经元的视觉感受野。接受野的大小和偏心率进行了比较，在邻近地区7a。研究的第二部分使用氚化氨基酸注射和荧光逆行示踪剂直接放置到LIP区的不同吻尾侧和背腹侧部分，研究了LIP区神经元的皮质-皮质连接。LIP区的感受野是通过体感5区进入的，这消除了示踪剂扩散到7a区的可能性。与许多7a区的感受野不同，LIP区的感受野要小得多，并且仅限于对侧视野。在LIP区，当记录电极切向移动到皮层表面并穿过LIP区的深处时，视觉感受野的有序进展是明显的。然而，整体视觉感受野组织，只产生了一个粗略的地形与一些重复的感受野表示在一个给定的rostrocaudal或背腹侧部分的LIP。中央视野代表通常位于沟内的更背侧，而周边视野则位于沟内的更腹侧。下视野更靠前，上视野更靠后。在LIP中，感受野的大小随着偏心率的增加而增加，但在样本中有很大的差异。LIPv区与许多纹外视区有相互的皮质-皮质联系，包括顶枕视区PO; V3、V3A和V4区;中颞区（MT）;中上级颞区（MST）;背侧月前区（DP）;和TEO区（颞内皮层的枕区）。区域LIPv也连接到外侧后海马旁回中的区域TF。尽管LIPd区与LIPv区有许多相同的皮质-皮质连接，但仍存在一些明显差异。区域LIPd而不是LIPv与视觉区域TEa和TEm（颞内皮层的前部和内侧分区）以及与上级颞沟中的多模态区域IPa（上级颞皮层尾侧库中的联合皮层的细分）有联系。区域LIP（包括LIPv和LIPd）的吻尾侧部分与前额叶皮层的外侧内侧部分之间的地形关系也很明显，横跨区域8a（额叶眼区）和区域46的内侧部分。LIP与顶下小叶其他区域的内在联系包括向7a区的前馈投射，以及与双峰腹侧顶内区（VIP）和躯体感觉区7b（PF）的联系。在区域5中观察到一些逆行标记的细胞，但这种投射未被放置在顶内沟内侧库（区域PEa）的对照注射所证实。有趣的...
The visual receptive field physiology and anatomical connections of the lateral intraparietal area (area LIP), a visuomotor area in the lateral bank of the inferior parietal lobule, were investigated in the cynomolgus monkey (Macaca fascicularis). Afferent input and physiological properties of area 5 neurons in the medial bank of the intraparietal sulcus (i.e., area PEa) were also determined. Area LIP is composed of two myeloarchitectonic zones: a ventral zone (LIPv), which is densely myelinated, and a lightly myelinated dorsal zone (LIPd) adjacent to visual area 7a. Previous single‐unit recording studies in our laboratory have characterized visuomotor properties of area LIP neurons, including many neurons with powerful saccade‐related activity. In the first part of the present study, single‐unit recordings were used to map visual receptive fields from neurons in the two myeloarchitectonic zones of LIP. Receptive field size and eccentricity were compared to those in adjacent area 7a. The second part of the study investigated the cortico‐cortical connections of area LIP neurons using tritiated amino acid injections and fluorescent retrograde tracers placed directly into different rostrocaudal and dorsoventral parts of area LIP. The approach to area LIP was through somatosensory area 5, which eliminated the possibility of diffusion of tracers into area 7a.Unlike many area 7a receptive fields, which are large and bilateral, area LIP receptive fields were much smaller and exclusively confined to the contralateral visual field. In area LIP, an orderly progression in visual receptive fields was evident as the recording electrode moved tangentially to the cortical surface and through the depths of area LIP. The overall visual receptive field organization, however, yielded only a rough topography with some duplications in receptive field representation within a given rostrocaudal or dorsoventral part of LIP. The central visual field representation was generally located more dorsally and the peripheral visual field more ventrally within the sulcus. The lower visual field was represented more anteriorly and the upper visual field more posteriorly. In LIP, receptive field size increased with eccentricity but with much variability within the sample.Area LIPv was found to have reciprocal cortico‐cortical connections with many extrastriate visual areas, including the parieto‐occipital visual area PO; areas V3, V3A, and V4; the middle temporal area (MT); the middle superior temporal area (MST); dorsal prelunate area (DP); and area TEO (the occipital division of the intratemporal cortex). Area LIPv is also connected to area TF in the lateral posterior parahippocampal gyrus. Although area LIPd has many of the same cortico‐cortical connections as LIPv, some differences were apparent. Area LIPd and not LIPv has connections with visual areas TEa and TEm (anterior and medial divisions of the intratemporal cortex) and with multimodal area IPa (subdivision of association cortex in caudal bank of superior temporal cortex) in the superior temporal sulcus. A topographic relationship between rostrocaudal parts of area LIP (including both LIPv and LIPd) and the lateromedial parts of prefrontal cortex across areas 8a (frontal eye fields) and the medial portion of area 46 was also apparent. Intrinsic connections of LIP with other areas in the inferior parietal lobule included a feedforward projection to area 7a and connections with the bimodal ventral intraparietal area (VIP) as well as with somatosensory area 7b (PF). Some retrogradely labeled cells were seen in area 5, but this projection was not confirmed by control injections placed in the medial bank of the intraparietal sulcus (area PEa). An interesting …