Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles
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DOI：
10.1093/bioinformatics/btg307
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发表时间：
2003-11-22
期刊：
影响因子：
5.8
通讯作者：
Ingber, DE
中科院分区：
文献类型：
--
作者：
Eichler, GS;Huang, S;Ingber, DE
全基因组表达谱包含在当前基因聚类分析中难以通过视觉检测到的全局模式。在此，描述了一种基因表达动态监测器（GEDI），它利用自组织映射将时间进程或样本类别的高维表达谱转化为动态的、连贯的且稳健的镶嵌图像。GEDI有助于在基因、时间和样本空间中同时识别有趣的分子活动模式，而无需事先假设数据中的任何结构，然后允许用户检索感兴趣的基因。基于“格式塔”识别，可以快速识别全基因组活动中的重要变化，因此，GEDI对于非专业终端用户（如医生）可能特别有用。
Genome-wide expression profiles contain global patterns that evade visual detection in current gene clustering analysis. Here, a Gene Expression Dynamics Inspector (GEDI) is described that uses self-organizing maps to translate high-dimensional expression profiles of time courses or sample classes into animated, coherent and robust mosaics images. GEDI facilitates identification of interesting patterns of molecular activity simultaneously across gene, time and sample space without prior assumption of any structure in the data, and then permits the user to retrieve genes of interest. Important changes in genome-wide activities may be quickly identified based on 'Gestalt' recognition and hence, GEDI may be especially useful for non-specialist end users, such as physicians.