Novel Pentacyclic seco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties from Illicium jiadifengpi
Novel Pentacyclic seco-Prezizaane-Type Sesquiterpenoids with Neurotrophic Properties from Illicium jiadifengpi
复制标题
DOI：
10.1021/ol9021029
复制
发表时间：
2009-11-19
期刊：
影响因子：
5.2
通讯作者：
Fukuyama, Yoshiyasu
中科院分区：
文献类型：
--
作者：
Kubo, Miwa;Okada, Chihiro;Fukuyama, Yoshiyasu
从加地枫皮中分离得到3个新的裂裂型倍半萜类化合物，分别为加地芬内酯（1）、加地芬恶茂烷A（2）和加地芬恶茂烷B（3）。通过2D-NMR方法、化学转化和单晶X-射线分析确定了它们的五环笼状结构。化合物1和2在0.01至10 μ M的浓度范围内强烈促进原代培养的大鼠皮质神经元中的神经突生长。
Three novel seco-prezizaane-type sesquiterpenoids, jiadifenolide (1), jiadifenoxolane A (2), and jiadifenoxolane B (3), were isolated from the pericarps of Illicium jiadifengpi. Their pentacyclic cage structures were determined by 2D-NMR methods, chemical conversion, and single-crystal X-ray analysis. Compounds 1 and 2 strongly promote neurite outgrowth in primary cultured rat cortical neurons at concentrations ranging from 0.01 to 10 mu M.