The effects of frequency in pallidal deep brain stimulation for primary dystonia
The effects of frequency in pallidal deep brain stimulation for primary dystonia
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DOI：
10.1007/s00415-003-0179-0
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发表时间：
2003-10-01
影响因子：
6
通讯作者：
Trottenberg, T
中科院分区：
文献类型：
--
作者：
Kupsch, A;Klaffke, S;Trottenberg, T
通过随机双盲方法，对5例全身性或节段性肌张力障碍患者术后3 - 12个月进行白斑深部脑刺激频率的效果评估。使用130赫兹的频率，生活质量和张力障碍症状的严重程度分别改善了约60%和43%。与130 Hz相比，在180和250 Hz频率下观察到显著的进一步临床改善，而与130 Hz相比，在较低频率（5,50 Hz）下则明显恶化。
The effect of stimulation frequency for pallidal deep brain stimulation in five patients with either generalized or segmental dystonia was evaluated three to twelve months postoperatively via a randomized, double-blind paradigm. The quality of life and the severity of dystonic symptoms improved by approximately 60% and 43% respectively using a frequency of 130 Hz. Compared with 130 Hz a significant further clinical improvement was observed at frequencies of 180 and 250 Hz, which contrasted with a significant deterioration at lower frequencies (5, 50 Hz) compared to 130 Hz.