The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans.
The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans.
复制标题
遭受原子弹袭击的父母的孩子：人类基因双倍辐射剂量的估计。
DOI：
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发表时间：
1990
影响因子：
9.8
通讯作者：
Yasuhiko Yoshimoto
中科院分区：
文献类型：
--
作者：
James V. Neel;W. Schull;A. A. Awa;Chiyoko Satoh;Hiroo Kato;Masanori Otake;Yasuhiko Yoshimoto
过去40年来在广岛和长崎收集的关于原子弹爆炸幸存者的子女和适当控制人口的子女的数据，是根据最新订正的辐射剂量估计数进行分析的。在8个不同的指标上没有出现统计学上显著的影响。然而，由于可以有把握地假定某些突变是诱导的，我们对数据进行了表面处理，并计算了各个指标在不同概率水平下急性辐射的最小配子加倍剂量。还努力计算这些综合指标最可能加倍的剂量。后者的值在1.7 - 2.2 Sv之间。建议适当的慢性辐射量在3.4至4.5西沃特之间。这些估计表明，人类对辐射的遗传影响并不像过去根据小鼠实验推断的那样敏感。
The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice.
描述和验证从人口数据同时估计有效人口规模和突变率的方法。
DOI：
10.1073/pnas.86.23.9407
发表时间：
1989
影响因子：
11.1
作者：
Chakraborty,R;Neel,JV
通讯作者：
Neel,JV