Transcriptomic changes in brain development.
Transcriptomic changes in brain development.
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DOI：
10.1016/b978-0-12-801105-8.00009-6
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发表时间：
2014
影响因子：
--
通讯作者：
Cookson MR
中科院分区：
文献类型：
--
作者：
Dillman AA;Cookson MR
转录组在大脑发育过程中发生了巨大的变化。与RNA编辑相关的整个基因、交替外显子和单碱基对变化都显示出胚胎和成熟大脑之间的差异。总的来说，随着大脑的发育，这些变化控制着蛋白质组的多样性。此外，非编码RNA（miRNA和lncRNA）中存在许多变化，其与mRNA相互作用以影响整体转录景观。在这里，我们将讨论什么是已知的大脑发育中的这种变化，特别是集中在高通量的方法，以及如何可以用来推断基因表达的机制，在大脑中控制它的成熟。
The transcriptome changes hugely during development of the brain. Whole genes, alternate exons and single base pair changes related to RNA editing all show differences between embryonic and mature brain. Collectively, these changes control proteomic diversity as the brain develops. Additionally, there are many changes in non-coding RNAs (miRNA and lncRNA) that interact with mRNA to influence the overall transcriptional landscape. Here we will discuss what is known about such changes in brain development, particularly focussing on high throughput approaches and how those can be used to infer mechanisms by which gene expression is controlled in the brain as it matures.