The making of filopodia
The making of filopodia
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DOI：
10.1016/j.ceb.2005.11.002
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发表时间：
2006-02-01
影响因子：
7.5
通讯作者：
Rottner, K
中科院分区：
文献类型：
--
作者：
Faix, J;Rottner, K
丝状伪足是细胞表面的杆状突起，充满一束束平行的肌动蛋白细丝。它们存在于各种类型的细胞上，并被归因于感觉或探索功能。丝状基团的形成通常与片状肌动蛋白细丝阵列的突起有关，称为片状脂膜和膜褶皱，但与这些结构相比，支持丝状基团的启动和维持的分子细节才刚刚开始出现。最近的进展提高了我们对丝足突起的分子要求的理解，并对片脂和丝足之间的相互关系有了深入的了解，这是突出的肌动蛋白细胞骨架的两个‘亚室’。
Filopodia are rod-like cell surface projections filled with bundles of parallel actin filaments. They are found on a variety of cell types and have been ascribed sensory or exploratory functions. Filopodium formation is frequently associated with protrusion of sheet-like actin filament arrays called lamellipodia and membrane ruffles, but, in comparison to these structures, the molecular details underpinning the initiation and maintenance of filopodia are only just beginning to emerge. Recent advances have improved our understanding of the molecular requirements for filopodium protrusion and have yielded insights into the inter-relationships between lamellipodia and filopodia, the two 'sub-compartments' of the protrusive actin cytoskeleton.