Frequency analysis of atrial fibrillation
Frequency analysis of atrial fibrillation
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DOI：
10.1109/cic.2000.898456
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发表时间：
2000-09
期刊：
影响因子：
--
通讯作者：
P. Langley;J. Bourke;Alan Murray
中科院分区：
文献类型：
--
作者：
P. Langley;J. Bourke;Alan Murray
心房颤动（AF）是一种常见的心律失常，可造成严重的临床后果。房颤的不同特征可能更适合治疗，但由于心房复合波相对于心室复合波较小，因此不容易从ECG记录中评估心房节律的特征。房颤通常在ECG上表现为明显不规则的基线偏离。我们的目的是开发一种技术，使研究人员能够从体表心电图中无创地检索有关房性心律的信息，并评估房性心律的稳定性。我们同时记录了6名房颤患者300 s 500 Hz的12导联心电图，并直接输入计算机进行后续分析。为了进行稳定性分析，我们将300 s的记录分成两个部分，每个部分150 s。然后将其细分为约10 s的部分，并对每个12导联部分进行主成分分析，生成12个正交数据分量。使用快速傅立叶变换算法对每个分量进行频率分析，并计算每个150 s部分的平均频谱。由此，从5和10 Hz之间的频谱中的峰值识别主AF频率。在主成分6、7和8中最常观察到心房波形，受试者的平均（SD）频率为6.8 Hz（0.9 Hz），范围为5.9 Hz至8.2 Hz。成对的150 s切片之间的差异为0.3 Hz（0.3 Hz），表明可以一致地识别主心房频率，并且短期变异性很小。
Atrial fibrillation (AF) is a common arrhythmia which can have serious clinical consequences. Different characteristics of AF may be more amenable to treatment, but it is not easy to assess the characteristics of the atrial rhythm from ECG recordings since the atrial complexes are small relative to the ventricular complexes. AF is usually seen on the ECG as apparently irregular deviations of the baseline. Our aim was to develop a technique which would allow researchers to retrieve information about the atrial rhythm non-invasively from body-surface ECGs and to assess the stability of the atrial rhythm. We recorded 300 s of simultaneous 12-lead ECGs at 500 Hz directly to a computer from six patients with AF for subsequent analysis. For stability analysis, we split the 300 s recordings into two sections of 150 s each. These were then subdivided into sections of approximately 10 s, and principal component analysis was performed on each 12-lead section, generating 12 orthogonal data components. A frequency analysis of each component was carried out using a fast Fourier transform algorithm and the average spectrum calculated for each 150 s section. From this the dominant AF frequency was identified from the peak in the spectrum between 5 and 10 Hz. The atrial waveform was most commonly observed in principal components 6, 7 and 8 with mean (SD) frequency 6.8 Hz (0.9 Hz) and range 5.9 Hz to 8.2 Hz across the subjects. The difference between the paired 150 s sections was 0.3 Hz (0.3 Hz), showing that the dominant atrial frequency could be identified consistently and that there was little short term variability.