IMMUNOCHEMICAL CHARACTERIZATION OF CIRCULATING PARATHYROID-HORMONE RELATED PROTEIN IN PATIENTS WITH HUMORAL HYPERCALCEMIA OF CANCER
IMMUNOCHEMICAL CHARACTERIZATION OF CIRCULATING PARATHYROID-HORMONE RELATED PROTEIN IN PATIENTS WITH HUMORAL HYPERCALCEMIA OF CANCER
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DOI：
10.1056/nejm199004193221603
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发表时间：
1990-04-19
影响因子：
158.5
通讯作者：
STEWART, AF
中科院分区：
文献类型：
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作者：
BURTIS, WJ;BRADY, TG;STEWART, AF
肿瘤患者的体液性高钙血症的癌症产生甲状旁腺相关蛋白（PTHRP）。我们已经开发了两个区域特异性免疫测定能够测量血浆中的PTHRP：针对PTHRP氨基酸序列1至74的免疫放射测定和针对PTHRP氨基酸序列109至138的放射免疫测定。60名正常受试者的血浆PTHRP（1至74）浓度较低或检测不到（平均值为1.9 pmol/L），PTHRP（109至138）浓度检测不到（
Tumors from patients with humoral hypercalcemia of cancer produce a parathyroid hormone-related protein (PTHRP). We have developed two region-specific immunoassays capable of measuring PTHRP in plasma: an immunoradiometric assay directed toward PTHRP amino acid sequence 1 to 74 and a radioimmunoassay directed toward PTHRP amino acid sequence 109 to 138. Sixty normal subjects had low or undetectable plasma PTHRP (1 to 74) concentrations (mean, 1.9 pmol per liter) and undetectable PTHRP (109 to 138) concentrations (