Do mutations causing low HDL-C promote increased carotid intima-media thickness?
Do mutations causing low HDL-C promote increased carotid intima-media thickness?
复制标题
导致低 HDL-C 的突变是否会促进颈动脉内膜中层厚度增加？
DOI：
10.1016/j.cca.2006.10.001
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Riley,Ward
中科院分区：
文献类型：
--
作者：
Miller,Michael;Rhyne,Jeffrey;Hong,SeungHo;Friel,Gina;Dolinar,Christina;Riley,Ward
BACKGROUND: Although observational data support an inverse relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease (CHD), genetic HDL deficiency states often do not correlate with premature CHD. METHODS: Carotid intima-media thickness (cIMT) measurements were obtained in cases comprising 10 different mutations in LCAT, ABCA1 and APOA1 to further evaluate the relationship between low HDL resulting from genetic variation and early atherosclerosis. RESULTS: In a 1:2 case-control study of sex and age-related (±5 y) subjects (n=114), cIMT was nearly identical between cases (0.66±0.17 cm) and controls (0.65±0.18 cm) despite significantly lower HDL cholesterol (0.67 vs. 1.58 mmol/l) and apolipoprotein A-I levels (96.7 vs. 151.4 mg/dl) (P<0.05) CONCLUSIONS: Genetic variants identified in the present study may be insufficient to promote early carotid atherosclerosis.
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