Effects of attention on orientation-tuning functions of single neurons in macaque cortical area V4
Effects of attention on orientation-tuning functions of single neurons in macaque cortical area V4
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DOI：
10.1523/jneurosci.19-01-00431.1999
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发表时间：
1999-01-01
影响因子：
5.3
通讯作者：
Maunsell, JHR
中科院分区：
文献类型：
--
作者：
McAdams, CJ;Maunsell, JHR
我们研究了注意如何影响两个恒河猴的纹外区V4和V1区的262个孤立的神经元和135个神经元的方向调谐。这些动物被训练来执行延迟的样本匹配任务，其中定向刺激呈现在被记录的神经元的感受野中。在一些试验中，动物被指示注意这些刺激，在其他试验中，他们被指示注意感受野之外的其他刺激。通过这种方式，定向调谐曲线可以从两种行为状态下收集的神经元反应中构建出来：一种是动物关注这些刺激，另一种是动物忽略这些刺激。我们将高斯函数拟合到神经元对每个行为状态的12个不同方向的反应。虽然注意力增强了V4神经元（中位数增加26%）和V1神经元（中位数增加8%）的反应，但选择性（通过其方向调谐曲线的宽度来测量）并没有被注意力系统地改变。注意力的影响是一致的乘法缩放的驱动响应的所有方向。我们还发现，注意力并没有引起神经元非驱动活动的系统性变化。
We examined how attention affected the orientation tuning of 262 isolated neurons in extrastriate area V4 and 135 neurons in area V1 of two rhesus monkeys. The animals were trained to perform a delayed match-to-sample task in which oriented stimuli were presented in the receptive field of the neuron being recorded. On some trials the animals were instructed to pay attention to those stimuli, and on other trials they were instructed to pay attention to other stimuli outside the receptive field. In this way, orientation-tuning curves could be constructed from neuronal responses collected in two behavioral states: one in which those stimuli were attended by the animal and one in which those stimuli were ignored by the animal. We fit Gaussians to the neuronal responses to twelve different orientations for each behavioral state. Although attention enhanced the responses of V4 neurons (median 26% increase) and V1 neurons (median 8% increase), selectivity, as measured by the width of its orientation-tuning curve, was not systematically altered by attention. The effects of attention were consistent with a multiplicative scaling of the driven response to all orientations. We also found that attention did not cause systematic changes in the undriven activity of the neurons.