Age, Gender and Geographic Differences in Global Health Burden of Cirrhosis and Liver Cancer due to Nonalcoholic Steatohepatitis.
Age, Gender and Geographic Differences in Global Health Burden of Cirrhosis and Liver Cancer due to Nonalcoholic Steatohepatitis.
复制标题
非酒精性脂肪性肝炎导致的肝硬化和肝癌全球健康负担的年龄、性别和地理差异
DOI：
10.7150/jca.52282
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发表时间：
2021
影响因子：
3.9
通讯作者：
Shan PF
中科院分区：
文献类型：
--
作者：
Zhang T;Xu J;Ye L;Lin X;Xu Y;Pan X;Weng X;Ye C;Fan L;Ren Y;Shan PF
目的：近年来，非酒精性脂肪性肝炎（NASH）已成为肝硬化和肝癌的主要病因。因此，使用2017年全球疾病负担（GBD）来全面分析1990年至2017年间NASH导致的肝硬化和肝癌的全球、地区和国家负担。方法：NASH所致肝硬化和肝癌的数据摘自2017年GBD研究。2017年的社会人口指数（SDI）被引用为社会经济地位的指标。建立ARIMA模型对未来卫生负担进行预测。采用Kruskal-Wallis检验和Pearson线性相关分析性别差异及其与社会经济水平的关系。结果如下：从1990年到2017年，NASH导致的肝癌的全球残疾调整生命年（Disability-Adjusted Life Years，DADs）数量从71万增加到146万。NASH导致肝癌的年龄标准化DADs率与SDI水平呈负相关（r=0. 409，p<0.001）。从地理上看，澳大拉西亚因NASH而导致的肝癌负担增加最多，年龄标准化的糖尿病发病率增加了143.54%。NASH导致的肝癌的全球患病人数在男性中在60-64岁达到峰值，在女性中在65-69岁达到峰值。从全球来看，男性的负担比女性重。非酒精性脂肪性肝炎肝癌患者的年龄标化糖尿病患病率的男女比例与SDI呈正相关（r=0.303，P=0.011）。结论：自1990年以来，NASH相关肝癌的全球负担显着增加，年龄，性别和地理差异。应强调公众对NASH所致肝病的认识。
Objective: Recently, Nonalcoholic Steatohepatitis (NASH) has become a major contributor to cirrhosis and liver cancer. Therefore, the Global Burden of Disease (GBD) 2017 was used to comprehensively analyze the global, regional, and national burden of cirrhosis and liver cancer due to NASH between 1990 and 2017. Methods: Data for cirrhosis and liver cancer due to NASH were extracted from the GBD study 2017. Socio-demographic Index (SDI) in 2017 was cited as indicators of socioeconomic status. ARIMA model was established to forecast the future health burden. Kruskal-Wallis test and Pearson linear correlation were adopted to evaluate the gender disparity and association with socioeconomic level. Results: From 1990-2017, the global disability-adjusted life years (DALYs) numbers of liver cancer due to NASH increased from 0.71 million to 1.46 million. The age-standardized DALYs rates of liver cancer due to NASH were negatively associated with SDI levels (r=0.-409, p<0.001). Geographically, Australasia experienced the largest increase in the burden of liver cancer due to NASH, with the age-standardized DALYs rate increasing by 143.54%. The global prevalence number of liver cancer due to NASH peaked at 60-64 years in males and at 65-69 years in females. Globally, the burden was heavier in males compared with females. Male-female-ratio of age-standardized DALYs rates in liver cancer due to NASH were positively related to SDI (r=0.303, P=0.011). Conclusion: The global burden of NASH-associated liver cancer has increased significantly since 1990, with age, gender and geographic disparity. Public awareness of liver diseases due to NASH should be emphasized.
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DOI：
10.1016/s0140-6736(18)31694-5
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
Foreman KJ;Marquez N;Dolgert A;Fukutaki K;Fullman N;McGaughey M;Pletcher MA;Smith AE;Tang K;Yuan CW;Brown JC;Friedman J;He J;Heuton KR;Holmberg M;Patel DJ;Reidy P;Carter A;Cercy K;Chapin A;Douwes-Schultz D;Frank T;Goettsch F;Liu PY;Nandakumar V;Reitsma MB;Reuter V;Sadat N;Sorensen RJD;Srinivasan V;Updike RL;York H;Lopez AD;Lozano R;Lim SS;Mokdad AH;Vollset SE;Murray CJL
通讯作者：
Murray CJL
DOI：
10.1016/s0140-6736(18)32225-6
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Risk Factor Collaborators
通讯作者：
GBD 2017 Risk Factor Collaborators
影响因子：
3.8
作者：
Ballestri S;Nascimbeni F;Baldelli E;Marrazzo A;Romagnoli D;Lonardo A
通讯作者：
Lonardo A
影响因子：
13.5
作者：
Sanyal, Arun J.;Harrison, Stephen A.;Goodman, Zachary
通讯作者：
Goodman, Zachary
影响因子：
10.3
作者：
Pan, Wen-Chi;Wu, Chih-Da;Yang, Hwai-I
通讯作者：
Yang, Hwai-I