Coordination of cell growth and division by the ubiquitin-proteasome system.
Coordination of cell growth and division by the ubiquitin-proteasome system.
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DOI：
10.1016/j.semcdb.2012.04.005
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发表时间：
2012-07
影响因子：
7.3
通讯作者：
Benanti, Jennifer A.
中科院分区：
文献类型：
--
作者：
Benanti, Jennifer A.
The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box protein (SCF) family and Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.
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影响因子：
64.5
作者：
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通讯作者：
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