Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy
Assessment of health-related quality of life in Chinese patients with minimal hepatic encephalopathy
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DOI：
10.3748/wjg.v13.i21.3003
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发表时间：
2007-06-07
影响因子：
4.3
通讯作者：
Zeng, Min-De
中科院分区：
文献类型：
--
作者：
Bao, Zhi-Jun;Qiu, De-Kai;Zeng, Min-De
目的：根据慢性肝炎，肝肝硬化患者，评估基于中国版本的SF-36和慢性肝病问卷（CLDQ），评估与健康相关的生活质量（HRQOL），包括最小.Methods：SF-36和CLDQ对160名健康志愿者进行了管理慢性肝炎和106例肝硬化患者（33例MHE）。在不同的研究组中比较了HRQOL评分。 SF-36包括八个健康概念：身体功能，角色物理，身体疼痛，一般健康，活力，社交功能，角色情绪和心理健康。评估了CLDQ的六个领域：腹部症状，疲劳，全身症状，活动，情绪功能和忧虑：与健康对照组相比（96.9 +/- 4.5，86.6 +/- 18.4，18.4，90.4，90.1 +/- 12.5，12.5，89.0 +/ +/ +/ +// +// -5.7，87.5 +/- 4.3，95.8 +/- 7.1，88.5 +/- 15.9， SF-36和6.7 +/- 0.5、6.1 +/- 0.6、6.3 +/- 0.6、6.5 +/- 0.5、6.3 +/- 0.5、6.3 +/- 0.5、6.8、6.8 +/- 0.4在SF-36中的88.7 +/- 5.2，患者与慢性肝炎B（86.3 +/- 11.0，68.8 +/- 21.3，78.9 +/- 14.4，60.8 +/- 10.5，70.8 +/- 8.6，76.1 +/- 12.6，50.0 +/- 22.9，72.2 +/- 10.6和5.5 +/- 1.0，4.5 +/- 1.0，1.0，5.2 +/- 1.1，1.1，5.3 +/- 0.9 4.8 +/- 0.9，4.9 +/- 1.0）和肝硬化（52.8 +/- 17.4，32.8 +/- 27.9， 61.6 +/- 18.9，30.2 +/- 18.3，47.9 +/- 20.1，54.0 +/- 19.2，28.9 +/- 26.1，51.1，51.1 +/- 17.8和4.7 +/- 1.2，3.9 +/- 1.2，3.9 +/- 1.2，1.2，4.7 + /-1.2，4.7 +/- 1.3，4.7 +/- 1.0，4.4 +/- 1.1）的HRQOL较低SF-36和CLDQ的所有尺度（所有人p <0.01）。肝硬化的严重程度的增加（基于儿童pugh得分/存在或MHE的存在）与大多数SF-36和CLDQ组成部分的降低有关，尤其是SF-36。判断：沿着SF-36的中文版本沿岸：SF-36使用CLDQ是一种有效且可靠的方法，用于测试肝硬化患者的MHE。肝硬化和MHE与HRQOL降低有关。 （c）2007年WJG出版社。版权所有。
AIM: To evaluate the health-related quality of life (HRQOL) based on the Chinese version of SF-36 and Chronic Liver Disease Questionnaire (CLDQ) in subjects with chronic hepatitis B, liver cirrhosis, including patients with minimal hepatic encephalopathy (MHE).METHODS: The SF-36 and CLDQ were administered to 160 healthy volunteers, 20 subjects with chronic hepatitis B and 106 patients with cirrhosis (33 cases exhibited MHE). HRQOL scores were compared among the different study groups. The SF-36 includes eight health concepts: physical functioning, role-physical, body pain, general health, vitality, social functioning, role-emotion, and mental health. Six domains of CLDQ were assessed: abdominal symptoms, fatigue, systemic symptoms, activity, emotional function and worry.RESULTS: Compared with healthy controls (96.9 +/- 4.5, 86.6 +/- 18.4, 90.1 +/- 12.5, 89.0 +/- 5.7, 87.5 +/- 4.3, 95.8 +/- 7.1, 88.5 +/- 15.9, 88.7 +/- 5.2 in SF-36 and 6.7 +/- 0.5, 6.1 +/- 0.6, 6.3 +/- 0.6, 6.5 +/- 0.5, 6.3 +/- 0.5, 6.8 +/- 0.4 in CLDQ), patients with chronic hepatitis B (86.3 +/- 11.0, 68.8 +/- 21.3, 78.9 +/- 14.4, 60.8 +/- 10.5, 70.8 +/- 8.6, 76.1 +/- 12.6, 50.0 +/- 22.9, 72.2 +/- 10.6 and 5.5 +/- 1.0, 4.5 +/- 1.0, 5.2 +/- 1.1, 5.3 +/- 0.9, 4.8 +/- 0.9, 4.9 +/- 1.0) and cirrhosis (52.8 +/- 17.4, 32.8 +/- 27.9, 61.6 +/- 18.9, 30.2 +/- 18.3, 47.9 +/- 20.1, 54.0 +/- 19.2, 28.9 +/- 26.1, 51.1 +/- 17.8 and 4.7 +/- 1.2, 3.9 +/- 1.2, 4.7 +/- 1.2, 4.7 +/- 1.3, 4.7 +/- 1.0, 4.4 +/- 1.1) had lower HRQOL on all scales of the SF-36 and CLDQ (P < 0.01 for all). Increasing severity of liver cirrhosis (based on the Child-Pugh score/presence or absence of MHE) was associated with a decrease in most components of SF-36 and CLDQ, especially SF-36.CONCLUSION: The Chinese version of SF-36 along with CLDQ is a valid and reliable method for testing MHE in patients with liver cirrhosis. Cirrhosis and MHE are associated with decreased HRQOL. (C) 2007 The WJG Press. All rights reserved.