Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics
Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Epigenetics
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DOI：
10.1093/gerona/gls110
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发表时间：
2012-07-01
影响因子：
5.1
通讯作者：
Tsai, Li-Huei
中科院分区：
文献类型：
--
作者：
Kosik, Kenneth S.;Rapp, Peter R.;Tsai, Li-Huei
基因表达的表观遗传调控在学习和记忆中起着重要作用，介导了经验对可塑性关键机制的影响。首脑会议开幕式上的发言者审查了关于表观遗传对与年龄有关的认知能力下降的作用的研究，并讨论了针对表观遗传机制制定干预措施的战略。演讲集中在经验依赖性DNA甲基化，microRNA的调节作用，组蛋白脱乙酰酶作为潜在的治疗靶点，以及探索表观遗传对大脑和认知老化的贡献的策略。这次会议建立了有用的里程碑，衡量在这一迅速发展的研究领域的进展。
Epigenetic regulation of gene expression plays an important role in learning and memory, mediating the influence of experience on critical mechanisms of plasticity. Speakers in the opening session of the Summit reviewed research on epigenetic contributions to age-related cognitive decline and discussed strategies for the development of interventions targeting epigenetic mechanisms. The presentations focused on experience-dependent DNA methylation, the regulatory role of microRNAs, histone deacetylases as potential therapeutic targets, and strategies for exploring epigenetic contributions to the aging of brain and cognition. This session established useful mileposts for gaging progress in this rapidly advancing area of research.