Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66
Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66
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DOI：
10.1086/513991
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发表时间：
1997-04-01
影响因子：
6.4
通讯作者：
Tanner, M
中科院分区：
文献类型：
--
作者：
Beck, HP;Felger, I;Tanner, M
在非洲进行的疟疾疫苗 SPf66 的第一个 III 期疗效试验中，通过聚合酶链反应 - 恶性疟原虫裂殖子表面抗原 2 (MSA2) 的限制性片段长度多态性分析了 SPf66 疫苗和安慰剂疫苗接种儿童的 MOIs。与无症状安慰剂接受者相比，无症状疫苗接受者的 MOI 显着降低；然而，在疫苗组和对照组中有症状的儿童中没有观察到差异。这些结果表明，SPf66 免疫调节了自然发生的感染的进程，如 MOI 降低所反映的那样。然而，在安慰剂接受者中，MSA2 确定的感染基因型数量与发病率之间存在显着的负相关。无症状安慰剂接受者平均有 5 例并发感染，而有临床病例的儿童平均有 3.4 例感染。这些数据进一步证明，并发感染的预免疫对于临床疟疾的免疫非常重要。在疫苗接种组中没有发现多重感染的这种影响。
In the first phase III efficacy trial of the malaria vaccine SPf66 in Africa, MOIs in SPf66- and placebo-vaccinated children were analyzed by polymerase chain reaction-restriction fragment length polymorphism of the Plasmodium falciparum merozoite surface antigen 2 (MSA2). MOIs were significantly reduced in asymptomatic vaccine recipients compared with those in asymptomatic placebo recipients; however, no differences were observed among symptomatic children in the vaccine and control groups. These results show that immunization with SPf66 modulates the course of naturally occurring infections, as reflected by reduced MOIs. In placebo recipients, however, there was a significant negative correlation between numbers of infecting genotypes, as identified by MSA2, and morbidity. Asymptomatic placebo recipients had an average of 5 concurrent infections, whereas children with clinical cases had an average of 3.4 infections. These data provide further evidence that premunition from concurrent infections is important in immunity against clinical malaria. No such effect of multiple infections was found in the vaccinated group.