Effects of Sodium Pentobarbital, Ketamine, Halothane, and Chloralose on Brainstem Auditory Evoked Responses
Effects of Sodium Pentobarbital, Ketamine, Halothane, and Chloralose on Brainstem Auditory Evoked Responses
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DOI：
10.1213/00000539-198204000-00005
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发表时间：
1982-04
影响因子：
5.7
通讯作者：
M. Cohen;R. Britt
中科院分区：
文献类型：
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作者：
M. Cohen;R. Britt
在猫中进行了一项参数研究，比较了手术室或实验室中使用的四种麻醉剂对脑干听觉诱发反应的影响：戊巴比妥钠、氯胺酮、氟烷和氯醛糖。以不同的顺序对4只猫中的每只给予每种麻醉剂。比较短声诱发脑干听觉诱发反应（BAER）的波形结构、潜伏期和成分峰幅度的差异。在使用每种麻醉剂的每只动物的脑干听觉诱发反应中可以识别出五个不同的峰（I至V）。麻醉剂之间组分峰的平均峰面积无统计学显著差异。使用相同麻醉剂的动物之间组分峰的振幅差异太大，无法进行有意义的比较。这项研究表明，点击诱发的脑干听觉反应是一个有用的手段，监测的完整性，在神经外科手术中的上升听觉通路的波形和成分峰的潜伏期不受各种胃肠外和吸入麻醉剂。
A parametric study was performed in cats comparing the effects on the brainstem auditory evoked response of four anesthetic agents used either in the operating room or the laboratory: sodium pentobarbital, ketamine, halothane, and Chloralose. Each anesthetic agent was administered to each of four cats in varying sequence. Click-evoked brainstem auditory evoked responses (BAER) were compared for differences in wave form configuration, latencies, and amplitudes of the component peaks. Five distinct peaks (I to V) could be identified in the brainstem auditory evoked responses of every animal using each anesthetic agent. There were no statistically significant differences in mean latencies of the component peaks among anesthetic agents. Amplitude differences of the component peaks between animals using the same anesthetic agent were too large to be meaningfully compared. This study suggests that the click-evoked brainstem auditory response is a useful means of monitoring the integrity of the ascending auditory pathway during neurosurgical procedures as the wave form and latencies of the component peaks are not affected by a variety of parenteral and inhalation anesthetic agents.