Biochemical coordination of plasma cell genesis.
Biochemical coordination of plasma cell genesis.
复制标题
浆细胞发生的生化协调。
DOI：
10.1111/imr.12992
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发表时间：
2021-09
影响因子：
8.7
通讯作者：
Allman D
中科院分区：
文献类型：
--
作者：
Gaudette BT;Allman D
Antibody-secreting plasma cells are a central component of short- and long-term adaptive immunity. Yet many fundamental questions about how activated B cells decide to yield functional plasma cells have yet to be answered. Likewise, the biochemical processes underpinning the ability of plasma cells to generate and secrete large numbers of antibodies, the capacity of some plasma cell to sustain antibody secretion, presumably without interruption, for decades, and the capacity of long-lived plasma cells to avoid apoptosis despite the high energy demands associated with sustained robust antibody synthesis and secretion each remain mysterious processes. Our objective here is to review what is currently known about these processes with an emphasis on the earliest phases of plasma cell genesis. Along the way we will work towards developing a model that ties the biochemistry of plasma cell function and survival. The chief idea imbedded in this model is that progress towards understanding plasma cell survival mechanisms may require increased focus on the unique cell autonomous processes inherent in plasma cell differentiation and function.
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影响因子：
3.7
作者：
Boeglin E;Smulski CR;Brun S;Milosevic S;Schneider P;Fournel S
通讯作者：
Fournel S
影响因子：
4.4
作者：
Gunn, Kathryn E.;Brewer, Joseph W.
通讯作者：
Brewer, Joseph W.
影响因子：
13.3
作者：
He C;Wang S;Zhou C;He M;Wang J;Ladds M;Lianoudaki D;Sedimbi SK;Lane DP;Westerberg LS;Li S;Karlsson MCI
通讯作者：
Karlsson MCI
DOI：
10.1073/pnas.1322420111
发表时间：
2014-04-29
影响因子：
11.1
作者：
Dowling, Mark R.;Kan, Andrey;Hodgkin, Philip D.
通讯作者：
Hodgkin, Philip D.
DOI：
10.1038/nri3383
发表时间：
2013-02
期刊：
Nature reviews. Immunology
影响因子：
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作者：
通讯作者：
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