Protective effects of Enterococcus faecium strain R30 supplementation on decreased muscle endurance under disuse in rats
Protective effects of Enterococcus faecium strain R30 supplementation on decreased muscle endurance under disuse in rats
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DOI：
10.1113/ep089677
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发表时间：
2021-07
影响因子：
2.7
通讯作者：
Minoru Tanaka;Takuya Ikeji;R. Nakanishi;T. Hirabayashi;Kohei Ono;Yusuke Hirayama;A. Tategaki;
中科院分区：
文献类型：
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作者：
Minoru Tanaka;Takuya Ikeji;R. Nakanishi;T. Hirabayashi;Kohei Ono;Yusuke Hirayama;A. Tategaki;
这项研究的中心问题是什么？屎肠球菌菌株 R30 (R30)（一种用于补充的新型乳酸菌株）是否可以通过改变萎缩骨骼肌的自主神经系统来减弱整个肌肉纤维类型从慢肌纤维向快肌纤维的转变？主要发现及其重要性是什么？补充 R30 可以通过上调过氧化物酶体增殖物激活受体-γ 共激活剂-1α 并激活激活 T 细胞信号通路的钙调磷酸酶-核因子，从而减弱与废用相关的肌肉耐力下降，从而减弱整个肌纤维类型从慢肌纤维向快肌纤维的转变。
What is the central question of this study? Does Enterococcus faecium strain R30 (R30), a new lactic acid bacterial strain for supplementation, attenuate shifts in the typology of whole muscle fibres from slow‐ to fast‐twitch by altering the autonomic nervous system in atrophied skeletal muscles? What is the main finding and its importance? R30 supplementation may attenuate the shifts in the typology of whole muscle fibres from slow‐ to fast‐twitch fibres by upregulating peroxisome proliferator‐activated receptor‐γ coactivator‐1α and activating the calcineurin–nuclear factor of activated T‐cells signalling pathway, thus ameliorating the decrease in muscle endurance associated with disuse.