Retrospective clonal analysis of the cerebellum using genetic laacZ/lacZ mouse mosaics.
Retrospective clonal analysis of the cerebellum using genetic laacZ/lacZ mouse mosaics.
复制标题
使用遗传 laacZ/lacZ 小鼠嵌合体对小脑进行回顾性克隆分析。
作者：
L. Mathis;C. Bonnerot;Luis Puelles;Jean
小鼠小脑中lacZ神经元克隆的分析表明，原发性和继发性生殖上皮细胞（PGE和SGE）在早期发育中具有谱系独立性。PGE前体及其神经元后代被组织成两个大小相似的多克隆组，它们表现出旁矢状图案并通常尊重中线。这两组细胞之间的关系无法及时追溯到少于80个独立细胞，这些细胞可能是在一段时间的非连贯生长后招募的，该生长将不相关的细胞分配到神经管的不同区域。一个lateromedial克隆组织中观察到的成熟小脑，这表明存在许多小paraschoptera域的克隆限制和/或细胞分散在rostrocaudal，但不是在mediolateral尺寸。该组织与神经管中的细胞组织正交，遗传组织也是如此。因此，小脑的细胞和遗传模式具有相似性。一个可能的假设是，不同的细胞行为产生了本研究中观察到的不同克隆域，并且小脑的细胞和遗传组织是协调的。
Analysis of lacZ neuronal clones in the mouse cerebellum demonstrates genealogical independence of the primary and secondary germinal epithelia (PGE and SGE) from early development. PGE precursors and their neuronal descendants are organised into two polyclonal groups of similar sizes that exhibit parasagittal patterning and generally respect the midline. The relationship between these two groups cannot be traced back in time to less than 80 independent cells, which were probably recruited following a period of non-coherent growth that distributes unrelated cells into distinct territories of the neural tube. A lateromedial clonal organisation is observed in the mature cerebellum, suggesting the existence of many small parasagittal domains of clonal restriction and/or of cell dispersion in the rostrocaudal but not in the mediolateral dimension. The organisation is orthogonal with respect to the cellular organisation in the neural tube as is the genetic organisation. Cellular and genetic patterning of the cerebellum therefore share similarities. A possible hypothesis is that distinct cell behaviours create the different clonal domains observed in this study and that the cellular and genetic organisation of the cerebellum are coordinated.
发育交感神经元中转录因子基因表达和表型标记的差异调节。
DOI：
10.1242/dev.121.3.887
发表时间：
1995
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Groves,AK;George,KM;Tissier-Seta,JP;Engel,JD;Brunet,JF;Anderson,DJ
通讯作者：
Anderson,DJ
小鼠小脑浦肯野细胞之间细胞谱系关系的理论和实验研究。
影响因子：
2.7
作者：
Vogel,MW;Herrup,K
通讯作者：
Herrup,K
Otx2 基因表达的尾部限制作为中脑/后脑边界的标记：一项使用原位杂交和小鸡/鹌鹑同位移植的研究。
DOI：
10.1242/dev.122.12.3785
发表时间：
1996
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Millet,S;Bloch-Gallego,E;Simeone,A;Alvarado-Mallart,RM
通讯作者：
Alvarado-Mallart,RM