The role of hydrogen sulfide in aging and age-related pathologies.
The role of hydrogen sulfide in aging and age-related pathologies.
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DOI：
10.18632/aging.101026
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发表时间：
2016-09-27
期刊：
影响因子：
--
通讯作者：
Bos EM
中科院分区：
文献类型：
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作者：
Perridon BW;Leuvenink HG;Hillebrands JL;van Goor H;Bos EM
当人类变老时，他们会经历不可避免的和渐进的生理功能丧失，最终导致死亡。对衰老的研究主要集中在识别衰老过程中涉及的机制。最近，几种提出的衰老理论被结合起来作为“衰老的标志”。这些标志描述了（病理）生理过程，当被破坏时，共同决定衰老表型。持续的证据表明，硫化氢（H2S）在调节衰老中的潜在作用。现在，H2S被认为是一种内源性产生的信号分子，具有多种（病理）生理效应。H2S涉及多种疾病，包括与衰老相关的病理学。在这篇评论中，已知的，假设和假设的硫化氢对衰老过程的影响将讨论通过审查其行动的老化的标志和几个年龄相关的病理。
When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the ‘hallmarks of aging’. These hallmarks describe (patho-)physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H2S) in the regulation of aging. Nowadays, H2S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H2S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies.