Blood Group Antigens
Blood Group Antigens
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血型抗原
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
T. Feizi
中科院分区：
文献类型：
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作者：
T. Feizi
I和i抗原是称为冷凝集素的红细胞自身抗体的最常见靶标（Dacie 1962，Marsh & Jenkins 1960）。大多数成人的红细胞上均存在I抗原（Wiener et al. 1956）。i抗原在脐带血细胞上强烈表达;在生命的第一年，I抗原增加到成人水平，i抗原减少（Marsh 1961）。少数健康成人（约万分之一）缺乏红细胞I抗原，但I抗原表达良好。在某些与骨髓应激相关的免疫疾病中，例如重型地中海贫血，红细胞i抗原的表达增加（Giblet & Crookston 1964）。这两种抗原均存在于白细胞上（Franks 1966，Shumak et al. 1971，托马斯1973）。
The I and i antigens are the most common targets of the red cell autoantibodies which are known as cold agglutinins (Dacie 1962, Marsh & Jenkins 1960). The I antigen is well represented on the red cells of the majority of adults (Wiener et al. 1956). The i antigen is strongly expressed on cord blood cells; in the course of the first year of life the I antigen increases to adult levels and the i antigen diminishes (Marsh 1961). Rare healthy adults (approximately one in ten thousand) lack the red cell I antigen and have i antigen well expressed. In certain hmmatological disorders associated with bone marrow stress, e.g. thalasssemia major, there is increased expression of erythrocyte i antigen (Giblet & Crookston 1964). Both of these antigens are present on leukocytes (Franks 1966, Shumak et al. 1971, Thomas 1973).