Sutureless amniotic membrane transplantation for severe bacterial keratitis.
Sutureless amniotic membrane transplantation for severe bacterial keratitis.
复制标题
DOI：
10.1097/ico.0b013e3181a2abad
复制
发表时间：
2009-12
期刊：
影响因子：
2.8
通讯作者：
Tseng SC
中科院分区：
文献类型：
--
作者：
Sheha H;Liang L;Li J;Tseng SC
评估早期无缝线羊膜移植治疗严重细菌性角膜炎的疗效，以减轻疼痛、炎症和混浊并促进愈合。非比较病例系列包括 3 名连续患有严重细菌性角膜炎的患者的 3 只眼睛，其表现出持续性上皮缺损/溃疡，直径超过 5 毫米，位于距视轴 3 毫米以内，浸润占角膜厚度的 50% 以上。通过 ProKera 以及选择性局部抗生素和不含防腐剂的类固醇进行早期（即 96 小时内）无缝线羊膜移植后，对这些患者进行了回顾性审查。监测疼痛缓解、炎症、浑浊和角膜上皮愈合情况。 ProKera 在一只眼睛中插入一次，在另外两只眼睛中插入两次。所有病例的疼痛均显着缓解，炎症也显着减少。 3只眼睛中的2只眼睛的角膜上皮缺损和基质溃疡迅速愈合，同时视力提高。通过 ProKera 进行的临时无缝线羊膜移植可以在办公室轻松插入和更换羊膜，并在患有严重细菌性角膜炎的情况下进行早期干预，以促进上皮化，减少疼痛、混浊和炎症。这一结果证明了未来大规模系列对照研究的合理性。
To evaluate the efficacy of early sutureless amniotic membrane transplantation in the management of severe bacterial keratitis to reduce pain, inflammation, and haze, and to promote healing. A noncomparative case series including 3 eyes of 3 consecutive patients with severe bacterial keratitis exhibiting persistent epithelial defect/ulcer, more than 5 mm in diameter, located within 3mm from the visual axis with infiltration occupying more than 50% of the corneal thickness. They were retrospectively reviewed following early (ie, within 96 hours) sutureless amniotic membrane transplantation via ProKera together with selective topical antibiotics and preservative-free steroid. Pain relief, inflammation, haze, and corneal epithelial healing were monitored. ProKera was inserted once in 1 eye and twice in the other 2 eyes. Pain was significantly relieved and inflammation was markedly reduced in all cases. The corneal epithelial defect and stromal ulceration rapidly healed while visual acuity improved in 2 of the 3 eyes. Temporary sutureless amniotic membrane transplantation via ProKera allows easy insertion and replacement of the membrane in the office, as well as early intervention to promote epithelialization, reduce pain, haze and inflammation in cases with severe bacterial keratitis. This result justifies large series controlled studies in the future.