Placental glucose transporters in fetal intrauterine growth retardation and macrosomia
Placental glucose transporters in fetal intrauterine growth retardation and macrosomia
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DOI：
10.1159/000291493
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发表时间：
1997-01-01
影响因子：
2.1
通讯作者：
Heinonen, PK
中科院分区：
文献类型：
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作者：
Kainulainen, H;Jarvinen, T;Heinonen, PK
为了研究胎盘葡萄糖输送在胎儿生长中的作用，从足月胎盘中测定了两种葡萄糖转运蛋白（Glut 3和Glut 4）。这是通过免疫印迹法从胎儿宫内生长迟缓（IUGR，n = 6），巨大儿（n = 6），母亲糖尿病（n = 4）和正常足月（n = 8）的情况下，从胎盘膜样品的粗品。在所有患者组中仅检测到极低数量的Glut3和Glut4，并且其胎盘密度没有变化，这表明这些转运蛋白的表达不参与胎儿生长障碍。然而，出生体重与胎盘重量相对应，表明IUGR中Glut3和Glut4的总量减少，巨大儿中增加。
To investigate the role of placental glucose delivery in fetal growth, two glucose transporters (Glut3 and Glut4) were determined from term placentae. This was accomplished by immunoblotting from crude placental membrane samples from cases of fetal intrauterine growth retardation (IUGR, n = 6), macrosomia (n = 6), maternal diabetes mellitus (n = 4) and normal term (n = 8). Glut3 and Glut4 were detected in only very low numbers in all patient groups and there were no changes in their placental density, which suggests that the expression of these transporters is not involved in disorders of fetal growth. However, birth weight corresponded to placental weight, indicating that the total amount of Glut3 and Glut4 is reduced in IUGR and increased in macrosomia.