INFLUENCE OF VARIOUS PROSTAGLANDIN SYNTHESIS INHIBITORS ON DMH-INDUCED RAT COLON CANCER
INFLUENCE OF VARIOUS PROSTAGLANDIN SYNTHESIS INHIBITORS ON DMH-INDUCED RAT COLON CANCER
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DOI：
10.1007/bf02553001
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发表时间：
1984-01-01
影响因子：
3.9
通讯作者：
WEIHE, H
中科院分区：
文献类型：
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作者：
METZGER, U;MEIER, J;WEIHE, H
为了评价前列腺素合成抑制剂对DMH[二甲肼]诱导的结肠癌发生率的影响，将90只雄性Sprague-Dawley大鼠随机分配至：吲哚美辛20 mg/l饮用水、甲氨蝶呤50 mg/l饮用水或正常饮用水（对照组）。DMH每周皮下注射。注射（20毫克/公斤体重）在第一个20周。在开始给药和致癌物暴露后32周，处死动物并检查肠道肿瘤的数量、大小、位置和扩散。与对照组（88%）和甲氯芬那酸组（90%）相比，接受消炎痛的动物的结肠癌发病率（56%）显着降低（P < 0.005）。小肠肿瘤的相应数字分别为31%、46%和35%。吲哚美辛治疗组动物的肿瘤在数量、大小、位置或扩散方面与另一组动物的肿瘤没有差异，这表明吲哚美辛可能影响致癌过程本身，而不是既定疾病的自然过程。吲哚美辛显著降低了该动物模型中大肠癌的发病率，并且该观察结果可能对未来在人类高危群体中的化学预防研究具有一定的潜力（例如，溃疡性结肠炎、家族性息肉病）。
To evaluate the influence of inhibitors of prostaglandin synthesis on the incidence of DMH[dimethylhydrazine]-induced colon cancer, 90 male Sprague-Dawley rats were randomly assigned to: indomethacin 20 mg/l drinking water, meclofenamate 50 mg/l drinking water or normal drinking water (control group). DMH was given by weekly s.c. injections (20 mg/kg body wt) during the first 20 wk. Thirty-two weeks after the start of treatment and carcinogen exposure, the animals were killed and examined for the number, size, location and spread of intestinal tumors. Colon cancer incidence was significantly lower in animals receiving indomethacin (56%) compared with the control group (88%) and with the meclofenamate group (90%) (P < 0.005). The corresponding figures for tumors in the small intestine were 31, 46 and 35%, respectively. The tumors in indomethacin-treated animals did not differ in number, size, location or spread from tumors of the other group, suggesting that indomethacin might influence the carcinogenic process itself, rather than the natural course of the established disease. Indomethacin significantly reduces the incidence of large-bowel cancer in this animal model, and this observation may have some potential for future chemopreventive studies in human high-risk groups (e.g., ulcerative colitis, familial polyposis).