Antitumor agents 201.: Cytotoxicity of harmine and β-carboline analogs
Antitumor agents 201.: Cytotoxicity of harmine and β-carboline analogs
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DOI：
10.1016/s0960-894x(99)00598-3
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发表时间：
1999-12-06
影响因子：
2.7
通讯作者：
Lee, KH
中科院分区：
文献类型：
--
作者：
Ishida, J;Wang, HK;Lee, KH
在人类肿瘤细胞系组中评估了二十六个β-咔啉的体外细胞毒性。 Harmine (3) 对多种细胞系表现出显着的活性，包括三种具有不同耐药机制的耐药 KB 亚系。 α-(4-硝基苯甲胺) 去氢骆驼蓬碱 (16) 具有广泛的细胞毒性谱（针对 1A9、KB、SaOS-2、A549、SK-MEL-2、U-87-MG 和 MCF-7 细胞的 ED50 值为 0.3-1.2 mu g/mL）。 (C) 1999 年由爱思唯尔科学有限公司出版。保留所有权利。
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. alpha-(4-Nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 mu g/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.