Dietary intake of vegetables, fruit, and antioxidants and risk of ulcerative colitis: A case-control study in Japan
Dietary intake of vegetables, fruit, and antioxidants and risk of ulcerative colitis: A case-control study in Japan
复制标题
蔬菜、水果和抗氧化剂的膳食摄入量与溃疡性结肠炎的风险：日本的病例对照研究
DOI：
10.1016/j.nut.2021.111378
复制
发表时间：
2021
期刊：
影响因子：
4.4
通讯作者：
et al
中科院分区：
文献类型：
--
作者：
Miyake Yoshihiro;Tanaka Keiko;Nagata Chisato;et al
目的氧化应激被认为是溃疡性结肠炎（UC）的病因之一，但关于抗氧化剂摄入与UC发病风险之间关系的流行病学资料有限。本病例对照研究在日本的目的是检查之间的关联摄入的绿色和黄色蔬菜，其他蔬菜，水果，维生素C，维生素E，视黄醇，α-胡萝卜素，β-胡萝卜素，和隐黄质和UC risk.MethodsA共384例在4年内诊断UC和665对照组被列入研究。饮食摄入量和混杂因素的数据通过自我报告问卷获得。使用169项半定量食物频率问卷收集有关饮食因素的信息。调整了性别，年龄，吸烟，饮酒，阑尾炎的历史，UC的家族史，教育水平，和身体质量index.ResultsHigher摄入水平的其他蔬菜，维生素C和视黄醇与UC的风险降低独立相关。其他蔬菜极端四分位数之间的校正比值比为0.51（95%置信区间[CI]，0.34 - 0.76;趋势P ≤ 0.001），维生素C为0.45（95% CI，0.30 - 0.69，趋势P ≤ 0.001），视黄醇为0.64（95% CI，0.43 - 0.95，趋势P = 0.04）。绿色和黄色蔬菜、水果、维生素E、α-胡萝卜素、β-胡萝卜素或隐黄质的摄入量与UC风险之间没有相关性（趋势P = 0.29，0.56，0.89，0.20，0.69和0.22，respectively）。
ObjectivesOxidative stress is considered one of the etiologic factors involved in ulcerative colitis (UC), yet there is limited epidemiologic information regarding the relationship between antioxidant intake and the risk of UC. The aim of the present case-control study in Japan was to examine the association between intake of green and yellow vegetables, other vegetables, fruit, vitamin C, vitamin E, retinol, alpha-carotene, beta-carotene, and cryptoxanthin and UC risk.MethodsA total of 384 cases within 4 y of diagnosis with UC and 665 controls were included in the study. Data on dietary intake and confounders were obtained using a self-reported questionnaire. Information on dietary factors was collected using a 169-item semiquantitative food-frequency questionnaire. Adjustment was made for sex, age, pack-y of smoking, alcohol consumption, history of appendicitis, family history of UC, education level, and body mass index.ResultsHigher intake levels of other vegetables, vitamin C, and retinol were independently associated with a reduced risk of UC. The adjusted odds ratio between extreme quartiles was 0.51 (95% confidence interval [CI], 0.34−0.76;Pfor trend ≤ 0.001) for other vegetables, 0.45 (95% CI, 0.30−0.69,Pfor trend ≤ 0.001) for vitamin C, and 0.64 (95% CI, 0.43−0.95,Pfor trend = 0.04) for retinol. There were no associations between intake of green and yellow vegetables, fruit, vitamin E, alpha-carotene, beta-carotene, or cryptoxanthin and UC risk (Pfor trend = 0.29, 0.56, 0.89, 0.20, 0.69, and 0.22, respectively).ConclusionsIntake of other vegetables, vitamin C, and retinol was inversely associated with UC risk.